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Title:
METHOD OF FRIEDEL-CRAFTS ACYLATION OF ANILIDES
Document Type and Number:
WIPO Patent Application WO/2002/055483
Kind Code:
A1
Abstract:
An anilide is reacted with an acylating agent by using as a catalyst a tri(perfluoroalkane sulfonate) compound of any of the elements belonging to the groups 3 to 5 and the groups 13 to 15 in the periods 4 to 6 of the periodic and thus the acyl group in the benzene ring is bonded. Thus, ketoaniline derivatives which are useful as physiologically active compounds or intermediates in synthesizing the same are synthesized at a high reaction yield by the catalytic acylation.

Inventors:
Kobayashi, Shu (6-6-702, Sarugaku-cho 1-chom, Chiyoda-ku Tokyo, 101-0064, JP)
Application Number:
PCT/JP2002/000020
Publication Date:
July 18, 2002
Filing Date:
January 08, 2002
Export Citation:
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Assignee:
JAPAN SCIENCE AND TECHNOLOGY CORPORATION (1-8 Hon-cho 4-chome, Kawaguchi-shi, Saitama, 332-0012, JP)
Kobayashi, Shu (6-6-702, Sarugaku-cho 1-chom, Chiyoda-ku Tokyo, 101-0064, JP)
International Classes:
C07B61/00; C07C231/12; C07C233/33; C07C233/76; C07C269/06; C07C271/28; C07C303/40; C07C311/08; (IPC1-7): C07C231/12; C07B37/04; C07C233/33; C07C271/28; C07C303/40; C07C311/08
Foreign References:
JPH05320089A
JP2001145833A
JPH06135883A
Other References:
HACHIYA I. ET AL.: 'Hafnium(IV) trifluoromethanesulfonate, an efficient catalyst for the friedel-crafts acylation and alkylation reactions' BULL. CHEM. SOC. JPN. vol. 68, no. 7, 1995, pages 2053 - 2060, XP002951074
KOBAYASHI, S. ET AL.: 'Gallium nonafluorobutanesulfonate as an efficient catalyst in friedel-crafts acylation' SYNLETT. vol. 3, 2000, pages 403 - 405, XP002951075
KOBAYASHI, S. ET AL.: 'Catalytic friedel-crafts acylation of benzene, chlorobenzene and fluorobenzene using a novel catalyst system, hafnium triflate and trifluoromethanesulfonic acid' TETRAHEDRON LETT. vol. 39, no. 26, 1998, pages 4697 - 4700, XP004130899
See also references of EP 1359141A1
Attorney, Agent or Firm:
Nishizawa, Toshio (6F Mani-Building, 37-10 Udagawa-ch, Shibuya-ku Tokyo, 150-0042, JP)
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