Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD OF FRIEDEL-CRAFTS ACYLATION OF ANILIDES
Document Type and Number:
WIPO Patent Application WO/2002/055483
Kind Code:
A1
Abstract:
An anilide is reacted with an acylating agent by using as a catalyst a tri(perfluoroalkane sulfonate) compound of any of the elements belonging to the groups 3 to 5 and the groups 13 to 15 in the periods 4 to 6 of the periodic and thus the acyl group in the benzene ring is bonded. Thus, ketoaniline derivatives which are useful as physiologically active compounds or intermediates in synthesizing the same are synthesized at a high reaction yield by the catalytic acylation.

Inventors:
KOBAYASHI SHU (JP)
Application Number:
PCT/JP2002/000020
Publication Date:
July 18, 2002
Filing Date:
January 08, 2002
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
JAPAN SCIENCE & TECH CORP (JP)
KOBAYASHI SHU (JP)
International Classes:
C07B61/00; C07C231/12; C07C233/33; C07C233/76; C07C269/06; C07C271/28; C07C303/40; C07C311/08; (IPC1-7): C07C231/12; C07B37/04; C07C233/33; C07C271/28; C07C303/40; C07C311/08
Foreign References:
JPH05320089A1993-12-03
JP2001145833A2001-05-29
JPH06135883A1994-05-17
Other References:
HACHIYA I. ET AL.: "Hafnium(IV) trifluoromethanesulfonate, an efficient catalyst for the friedel-crafts acylation and alkylation reactions", BULL. CHEM. SOC. JPN., vol. 68, no. 7, 1995, pages 2053 - 2060, XP002951074
KOBAYASHI, S. ET AL.: "Gallium nonafluorobutanesulfonate as an efficient catalyst in friedel-crafts acylation", SYNLETT., vol. 3, 2000, pages 403 - 405, XP002951075
KOBAYASHI, S. ET AL.: "Catalytic friedel-crafts acylation of benzene, chlorobenzene and fluorobenzene using a novel catalyst system, hafnium triflate and trifluoromethanesulfonic acid", TETRAHEDRON LETT., vol. 39, no. 26, 1998, pages 4697 - 4700, XP004130899
See also references of EP 1359141A4
Attorney, Agent or Firm:
Nishizawa, Toshio (37-10 Udagawa-ch, Shibuya-ku Tokyo, JP)
Download PDF: