Title:
METHOD FOR GENE TRANSFER INTO THE ORGANELLES OF CELLS: DIRECT GENE TRANSFER TO MITOCHONDRIA
Document Type and Number:
WIPO Patent Application WO2006023956
Kind Code:
A3
Abstract:
Methods of gene transfer into cellular organelles are disclosed which provide the necessary conditions for genetic materials such as virus or recombinant DNA to be delivered directly into mitochondria from extracellular space in vitro or in vivo.Once inside the mitochondria, the genetic materials can then be translated according to the mitochondrial genetic code and mitochondrial versions of the proteins can be made. Other conditions and molecules can be added to enhance the delivery.
Inventors:
LEE HONG BOCK (US)
Application Number:
PCT/US2005/030064
Publication Date:
August 31, 2006
Filing Date:
August 23, 2005
Export Citation:
Assignee:
LEE HONG BOCK (US)
International Classes:
C12N15/86; C12N15/87
Foreign References:
| US5922687A | 1999-07-13 | |||
| US6100068A | 2000-08-08 | |||
| US6320101B1 | 2001-11-20 | |||
| US6562563B1 | 2003-05-13 |
Other References:
LIU F.: "Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA", GENE THER., vol. 6, no. 7, July 1999 (1999-07-01), pages 1258 - 1266, XP009036645
"Definition of Atmosphere. Merriam-Webster Online Dictionary page 1 of 1", XP003001944, Retrieved from the Internet [retrieved on 20060101]
"Definition of Atmosphere. Merriam-Webster Online Dictionary page 1 of 1", XP003001944, Retrieved from the Internet
Download PDF:
Previous Patent: MULTIPLE STATION INVENTORY CONTROL SYSTEM
Next Patent: IMPROVED SELECTION OF-PH DEPENDENT COMPOUNDS FOR IN VIVO THERAPY
Next Patent: IMPROVED SELECTION OF-PH DEPENDENT COMPOUNDS FOR IN VIVO THERAPY