METHOD FOR GENERATING HIGHLY ACTIVE HUMAN DENDRITIC CELLS FROM MONOCYTES

WIPO Patent Application WO2002088328

A8

The present invention relates to a process for deriving dendritic cells from mononuclear cells in culture comprising the step of putting in contact type I IFN with said mononuclear cells. Dendritic cells suitable as cellular adjuvants in prophylactic as well as therapeutic vaccination of animal and human beings, are obtainable thereby, after a single step treatment in a brief period of time. Dendritic cells obtainable thereby, pharmaceutical compositions including them, in particular a vaccine comprising said cells as active principle, and a method of treatment of a pathology associated with the presence of an antigen in human beings, are further objects of the invention, as well as a kit for deriving said dendritic cells and a method for the ex vivo expansion of T cells using them.

BELARDELLI FILIPPO (IT)
SANTINI STEFANO MARIA (IT)
PARLATO STEFANIA (IT)
DI PUCCHIO TIZIANA (IT)
LOGOZZI MARIANTONIA (IT)
LAPENTA CATERINA (IT)
FERRANTINI MARIA (IT)
SANTODONATO LAURA (IT)
D AGOSTINO GIUSEPPINA (IT)

PCT/EP2002/004709

February 13, 2003

April 29, 2002

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IST SUPERIORE SANITA (IT)
BELARDELLI FILIPPO (IT)
SANTINI STEFANO MARIA (IT)
PARLATO STEFANIA (IT)
DI PUCCHIO TIZIANA (IT)
LOGOZZI MARIANTONIA (IT)
LAPENTA CATERINA (IT)
FERRANTINI MARIA (IT)
SANTODONATO LAURA (IT)
D AGOSTINO GIUSEPPINA (IT)

C12N15/09; A61K35/14; A61K35/28; A61K39/00; A61K39/21; A61K39/245; A61K39/39; A61P31/00; A61P31/12; A61P35/00; C12N5/0784; C12N5/10; A61K35/12; (IPC1-7): C12N5/00

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