Title:
METHOD FOR GENERATING HYDROGEN-CONTAINING ORGAN PRESERVATION SOLUTION, AND HYDROGEN-CONTAINING ORGAN PRESERVATION SOLUTION
Document Type and Number:
WIPO Patent Application WO/2020/217575
Kind Code:
A1
Abstract:
In this method for generating a hydrogen-containing organ preservation solution, at a site for handling transplantation organs, hydrogen gas is injected from a hydrogen-storage-alloy canister into a flexible container in which an organ preservation solution is accommodated, the flexible container is caused to vibrate and the hydrogen gas is dissolved in the organ preservation solution, and the flexible container is opened to outside air and the interior pressure of the flexible container is reduced, whereby hydrogen in solution at or above a prescribed concentration is contained in the flexible container, and there is generated a hydrogen-containing organ preservation solution that is used for washing and/or preserving transplantation organs.
Inventors:
KOBAYASHI EIJI (JP)
SANO MOTOAKI (JP)
HASHIMOTO SOU (JP)
IINUMA KATSUHARU (JP)
NISHI ZENICHI (JP)
SANO MOTOAKI (JP)
HASHIMOTO SOU (JP)
IINUMA KATSUHARU (JP)
NISHI ZENICHI (JP)
Application Number:
PCT/JP2019/045790
Publication Date:
October 29, 2020
Filing Date:
November 22, 2019
Export Citation:
Assignee:
UNIV KEIO (JP)
DOCTORS MAN CO LTD (JP)
DOCTORS MAN CO LTD (JP)
International Classes:
A01N1/02; A61L27/36
Foreign References:
| JP2010241787A | 2010-10-28 | |||
| JP2018177683A | 2018-11-15 | |||
| JP2014201580A | 2014-10-27 | |||
| JP2013010771A | 2013-01-17 | |||
| JP2015150472A | 2015-08-24 |
Other References:
UCHIDA, HAJIME: "Efficacy of Hydrogen- Molecule-Containing Preservative Liquids Against Small Intestine Ischemia/Reperfusion Injury in Small Intestinal Transplantation in Pigs.", ORGAN BIOLOGY, vol. 20, no. 3, 2013, pages 103, XP009524621, ISSN: 1340-5152
ABE, TOYOFUMI ET AL.: "Hydrogen-Rich University of Wisconsin Solution Attenuates Renal Cold Ischemia- Reperfusion Injury", TRANSPLANTATION, vol. 94, no. 1, 2012, pages 14 - 21, XP055758828
NAKAO, ATSUNORI ET AL.: "A new hydrogen administration method for cardiac graft preservation.", HYDROGEN RICH WATER BATH ORGAN BIOLOGY, vol. 21, no. 2, 2014, pages 150 - 158, XP055758834
ABE, TOYOFUMI ET AL.: "Hydrogen-Rich University of Wisconsin Solution Attenuates Renal Cold Ischemia- Reperfusion Injury", TRANSPLANTATION, vol. 94, no. 1, 2012, pages 14 - 21, XP055758828
NAKAO, ATSUNORI ET AL.: "A new hydrogen administration method for cardiac graft preservation.", HYDROGEN RICH WATER BATH ORGAN BIOLOGY, vol. 21, no. 2, 2014, pages 150 - 158, XP055758834
Attorney, Agent or Firm:
YOSHIDA, Yoshiharu (JP)
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