METHOD OF IDENTIFYING MODULATORS OF PRESENILIN

WIPO Patent Application WO2001067097

A3

A method of identifying a modulator of presenilin function, the method comprising: (i) providing (a) a polypeptide capable of binding a presenilin, which polypeptide comprises the amino acid sequence of SEQ ID NO: 1 or a functional variant thereof, or a fragment of either thereof which is capable of binding to presenilin; (b) a presenilin or a variant thereof or a fragment of either thereof capable of binding to a polypeptide which comprises the amino acid sequence of SEQ ID NO: 1; (c) a test substance under conditions that would permit binding of a polypeptide (a) to a presenilin (b) in the absence of the test substance; (ii) monitoring presenilin mediated activity; and (iii) determining thereby whether the test substance is a modulator of presenilin activity, a modulator identified by a method of the invention and use of a modulator identified by a method of the invention in the treatment of Alzheimer's disease.

HALE RICHARD STEPHEN (GB)
ROWLEY ADELE (GB)
BLACKSTOCK WALTER (GB)

PCT/GB2001/001059

May 16, 2002

March 09, 2001

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GLAXO GROUP LTD (GB)
HALE RICHARD STEPHEN (GB)
ROWLEY ADELE (GB)
BLACKSTOCK WALTER (GB)

G01N33/68; (IPC1-7): G01N33/68

WO1999035501A1

1999-07-15

KEIRSEBILCK A ET AL: "MOLECULAR CLONING OF THE HUMAN P120 CTN CATENIN GENE (CTNND1): EXPRESSION OF MULTIPLE ALTERNATIVELY SPLICED ISOFORMS", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 50, 1998, pages 129 - 146, XP000864646, ISSN: 0888-7543
ANASTASIADIS PANOS Z ET AL: "The p120 catenin family: Complex roles in adhesion, signaling and cancer.", JOURNAL OF CELL SCIENCE, vol. 113, no. 8, April 2000 (2000-04-01), pages 1319 - 1334, XP002187294, ISSN: 0021-9533

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