Title:
METHOD OF IDENTIFYING TOXIC AGENTS USING NSAID-INDUCED DIFFERENTIAL GENE EXPRESSION IN LIVER
Document Type and Number:
WIPO Patent Application WO2001038579
Kind Code:
A3
Abstract:
The invention provides methods of identifying toxic agents, e.g., hepatotoxic agents, using differential gene expression. Also provided are methods of predicting the risk level and or injury type of NSAIDs. Also disclosed are novel nucleic acid sequences whose expression is differentially regulated by NSAIDs.
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Inventors:
GOULD-ROTHBERG BONNIE E (US)
DIPIPPO VINCENT A (US)
RAMSEH TENNORE M (US)
GERWEIN ROBERT W (US)
DIPIPPO VINCENT A (US)
RAMSEH TENNORE M (US)
GERWEIN ROBERT W (US)
Application Number:
PCT/US2000/032049
Publication Date:
February 14, 2002
Filing Date:
November 21, 2000
Export Citation:
Assignee:
CURAGEN CORP (US)
GOULD ROTHBERG BONNIE E (US)
DIPIPPO VINCENT A (US)
RAMSEH TENNORE M (US)
GERWEIN ROBERT W (US)
GOULD ROTHBERG BONNIE E (US)
DIPIPPO VINCENT A (US)
RAMSEH TENNORE M (US)
GERWEIN ROBERT W (US)
International Classes:
C12Q1/68; (IPC1-7): C12Q1/68; C12N5/10; C12N15/63; C07K14/47; C07K16/18; C07H21/04
Domestic Patent References:
| WO1999039200A1 | 1999-08-05 | |||
| WO1999027090A1 | 1999-06-03 | |||
| WO2000063435A2 | 2000-10-26 |
Other References:
A. BHATTACHARJEE ET AL.: "Molecular dissection of dimethylnitrosamine (DMN)-induced hepatotoxicity by mRNA differential display.", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 150, no. 1, May 1998 (1998-05-01), New York, NY, USA, pages 186 - 195, XP002174806
R. SHIMKETS ET AL.: "Gene expression analysis by transcript profiling coupled to a gene database query.", NATURE BIOTECHNOLOGY, vol. 17, no. 8, August 1999 (1999-08-01), New York, NY, USA, pages 798 - 803, XP002174807
M. BONALDO ET AL.: "Normalization and subtraction: Two approaches to facilitate gene discovery.", GENOME RESEARCH, vol. 6, no. 9, September 1996 (1996-09-01), USA, pages 791 - 806, XP002174808
R. SHIMKETS ET AL.: "Gene expression analysis by transcript profiling coupled to a gene database query.", NATURE BIOTECHNOLOGY, vol. 17, no. 8, August 1999 (1999-08-01), New York, NY, USA, pages 798 - 803, XP002174807
M. BONALDO ET AL.: "Normalization and subtraction: Two approaches to facilitate gene discovery.", GENOME RESEARCH, vol. 6, no. 9, September 1996 (1996-09-01), USA, pages 791 - 806, XP002174808
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