METHOD OF IDENTIFYING TRANSCRIPTIONAL FACTOR INDUCING THE PRODUCTION OF MONASCUS-ORIGIN PHYSIOLOGICALLY ACTIVE SUBSTANCE AND UTILIZATION THEREOF

Title:

METHOD OF IDENTIFYING TRANSCRIPTIONAL FACTOR INDUCING THE PRODUCTION OF MONASCUS-ORIGIN PHYSIOLOGICALLY ACTIVE SUBSTANCE AND UTILIZATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2008/023469

Kind Code:

A1

Abstract:

It is intended to provide a transcriptional factor which can comprehensively regulate the transcription of a plural number of genes in the citrinin biosynthesis system. Namely, a gene containing a polynucleotide comprising the base sequence represented by SEQ ID NO:1 is provided.

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Inventors:

NIHIRA TAKUYA (JP)
KINOSHITA HIROSHI (JP)

Application Number:

PCT/JP2007/054061

Publication Date:

February 28, 2008

Filing Date:

March 02, 2007

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Assignee:

UNIV OSAKA (JP)
NIHIRA TAKUYA (JP)
KINOSHITA HIROSHI (JP)

International Classes:

C12N15/00; C07K14/37; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09

Foreign References:

JP2004321176A

2004-11-18

Other References:

DATABASE GENBANK [online] SHIMIZU T., KINOSHITA H., NIHIRA T.: "Identification and in vivo functional analysis by gene disruption of ctnR, a positive regulator gene involved in citrinin biosynthesis in Monascus purpureus", XP003021098, Database accession no. (AB243687)
BOK J.W. ET AL.: "LaeA, a Regulator of Secondary Metabolism in Aspergillus spp", EUKARYOT. CELL, vol. 3, no. 2, 2004, pages 527 - 535, XP003021099
SHIMIZU T. ET AL.: "Polyketide Synthase Gene Responsible for Citrinin Biosynthesis in Monascus purpureus", APPL. ENVIRON. MICROBIOL., vol. 71, no. 7, 2005, pages 3453 - 3457, XP003021100

Attorney, Agent or Firm:

TANAKA, Mitsuo et al. (IMP Building 3-7, Shiromi 1-chome, Chuo-ku, Osaka-sh, Osaka 01, JP)

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