Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR IMPROVING OPTICAL PURITY OF 2-HYDROXYCARBOXYLIC ACID OR DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/157607
Kind Code:
A1
Abstract:
Provided is a method for improving the optical purity of optically active 2-hydroxycarboxylic acids that are useful as raw materials in the manufacture of drugs, agricultural chemicals, and industrial products. A method for improving the optical purity of hydroxycarboxylic acids represented by general formula (Ia) or (Ib) or derivatives thereof including a step for recrystallizing and obtaining a salt of a hydroxycarboxylic acid represented by general formula (IIIa) or (IIIb) after reacting hydroxycarboxylic acid represented by general formula (Ia) or (Ib) with at least one optically inactive base selected from the group consisting of alkali metal alkoxides and secondary amines in the presence of a solvent. (In the formula, R1 represents a C1-8 alkyl group, and R2 represents an alkali metal or secondary amine.)

Inventors:
YAMAZAKI, Yukiyoshi (Tokyo New Drug Research Laboratories, 2-17-43, Noguchi-cho, Higashimurayama-sh, Tokyo 22, 〒1890022, JP)
Application Number:
JP2014/059083
Publication Date:
October 02, 2014
Filing Date:
March 28, 2014
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KOWA COMPANY, LTD. (6-29, Nishiki 3-chome Naka-ku, Nagoya-sh, Aichi 25, 〒4608625, JP)
International Classes:
C07C51/487; C07B57/00; C07C51/43; C07C51/50; C07C59/01; C07C67/08; C07C69/675; C07D263/58; A61K31/423; A61P3/00; A61P3/06; A61P3/10; A61P9/00; A61P29/00; A61P43/00
Domestic Patent References:
WO2003014056A12003-02-20
WO2007013555A12007-02-01
WO2005023777A12005-03-17
WO2005023777A12005-03-17
WO2006090768A12006-08-31
WO2006093142A12006-09-08
WO2006129649A12006-12-07
WO2007013555A12007-02-01
WO2007023906A12007-03-01
Foreign References:
JPH01175956A1989-07-12
JP2000063321A2000-02-29
JP2004533490A2004-11-04
Other References:
MASAAKI NAKAHATA ET AL.: "The Preparation of Optically Pure 3-Hydroxyalkanoic Acid. The Enantioface-differentiating Hydrogenation of the C=O Double Bond with Modified Raney Nickel XXXVII.", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 55, no. 7, 1982, pages 2186 - 2189, XP055285781
TADASHI KIKUKAWA ET AL.: "The preparation of optically pure 3-hydeoxybutanoic acid and its homologues as the dibenzylammonium salt", CHEMISTRY LETTERS, 1987, pages 1267 - 1270, XP055285784
See also references of EP 2980061A4
J. ORG. CHEM., vol. 53, 1988, pages 2589 - 2593
J. ORG. CHEM., vol. 51, 1986, pages 1713 - 1719
CHIRALITY, vol. 51, 1996, pages 225 - 233
J. AM. CHEM. SOC., vol. 120, 1988, pages 4315 - 4353
NIPPON KAGAKU KAISHI, vol. 77, no. 2, 1956, pages 284
TETRAHEDRON: ASYMMETRY, vol. 18, 2007, pages 2394 - 2398
J. CHEM. SOC., vol. 177, 1954, pages 1460 - 1464
TETRAHEDRON, vol. 32, 1976, pages 1101 - 1106
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (Sawanotsuru Ningyocho Bldg, 1-3-8 Nihonbashi Ningyocho, Chuo-k, Tokyo 13, 〒1030013, JP)
Download PDF: