Title:
METHOD FOR IMPROVING PRODUCTION OF STREPTOMYCES POLYKETIDE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2020/233506
Kind Code:
A1
Abstract:
A method for improving the production of streptomyces polyketide compounds is provided. The method greatly improves the capability of the streptomyces polyketide compounds by strengthening a triacylglycerol decomposition pathway in streptomyces during the stationary phase. A method for switching the primary metabolism of streptomyces to the secondary metabolism, streptomyces producing polyketide compounds, and use thereof are also provided.
Inventors:
ZHANG LIXIN (CN)
WANG WEISHAN (CN)
LI SHANSHAN (CN)
LI ZILONG (CN)
TAN GAOYI (CN)
ZHANG JINGYU (CN)
WANG WEISHAN (CN)
LI SHANSHAN (CN)
LI ZILONG (CN)
TAN GAOYI (CN)
ZHANG JINGYU (CN)
Application Number:
PCT/CN2020/090452
Publication Date:
November 26, 2020
Filing Date:
May 15, 2020
Export Citation:
Assignee:
UNIV EAST CHINA SCIENCE & TECH (CN)
INST MICROBIOLOGY CAS (CN)
INST MICROBIOLOGY CAS (CN)
International Classes:
C12P17/18; C12N1/21; C12N15/01; C12R1/465
Domestic Patent References:
| WO2020060948A1 | 2020-03-26 | |||
| WO2002068613A1 | 2002-09-06 | |||
| WO2010080184A1 | 2010-07-15 |
Foreign References:
| CN104513840A | 2015-04-15 | |||
| CN107418925A | 2017-12-01 | |||
| CN1308682A | 2001-08-15 |
Other References:
WANG W ET AL.: "Harnessing the intracellular triacylglycerols fortiter improvement of polyketides in Streptomyces", NATURE BIOTECHNOLOGY, vol. 38,, no. 1,, 9 December 2019 (2019-12-09), XP036983382, ISSN: 1546-1696, DOI: 20200805155839PX
WANG S AND DENG H: "The X-factor: Enhanced β-oxidation on intracellular triacylglycerols enabling overproduction of polyketide drug-like molecules in microorganisms", SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, vol. 5, no. 1,, 25 January 2020 (2020-01-25), XP055757396, ISSN: 2405-805X, DOI: 20200805160057PX
WANG S AND DENG H: "The X-factor: Enhanced β-oxidation on intracellular triacylglycerols enabling overproduction of polyketide drug-like molecules in microorganisms", SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, vol. 5, no. 1,, 25 January 2020 (2020-01-25), XP055757396, ISSN: 2405-805X, DOI: 20200805160057PX
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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