Title:
METHOD FOR IMPROVING THE SOLUBILITY OF TRICYCLIC AMINO ALCOHOL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/025198
Kind Code:
A1
Abstract:
Compounds useful in the treatment and prevention of diabetes, obesity, hyperlipidemia and so on are provided in the form of oral preparations exhibiting good absorbability in the digestive tract. A method for improving the solubility of tricyclic amino alcohol derivatives of general formula (1) or salts thereof, characterized by using these derivatives or salts in the form of noncrystalline substance, wherein R?1¿ is lower alkyl or benzyl; * represents an asymmetric carbon atom; R?2¿ is hydrogen, halogeno, or hydroxyl; and A is a substituent represented by general formula (2) or (3), (wherein X is NH, O or S).
Inventors:
SUMITA YUKIO (JP)
SUZUKI KAZUMI (JP)
NASU MASAAKI (JP)
HARA TOSHIMI (JP)
SUZUKI KAZUMI (JP)
NASU MASAAKI (JP)
HARA TOSHIMI (JP)
Application Number:
PCT/JP2000/006715
Publication Date:
April 12, 2001
Filing Date:
September 28, 2000
Export Citation:
Assignee:
ASAHI CHEMICAL IND (JP)
SUMITA YUKIO (JP)
SUZUKI KAZUMI (JP)
NASU MASAAKI (JP)
HARA TOSHIMI (JP)
SUMITA YUKIO (JP)
SUZUKI KAZUMI (JP)
NASU MASAAKI (JP)
HARA TOSHIMI (JP)
International Classes:
A61K9/14; A61K9/16; A61K31/343; A61K31/381; A61K31/403; A61P3/04; A61P3/06; A61P3/10; C07D209/08; C07D209/88; C07D307/91; C07D333/76; (IPC1-7): C07D209/88; A61K9/14; A61K31/343; A61K31/381; A61K31/403; A61P3/04; A61P3/06; A61P3/10; C07D307/91; C07D333/76
Domestic Patent References:
| WO1997025311A1 | 1997-07-17 | |||
| WO1999001431A1 | 1999-01-14 | |||
| WO2000035890A1 | 2000-06-22 | |||
| WO2000058287A1 | 2000-10-05 | |||
| WO2000059885A1 | 2000-10-12 |
Other References:
See also references of EP 1219604A4
Attorney, Agent or Firm:
Hiraki, Yusuke (17-1 Toranomon 1-chome Minato-ku, Tokyo, JP)
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