Title:
METHOD FOR THE IN VITRO DIAGNOSIS OF THYROID DISEASES
Document Type and Number:
WIPO Patent Application WO/2017/064664
Kind Code:
A3
Abstract:
A method for the in vitro differential diagnosis of thyroid diseases is described comprising the step of determining by means of mass spectrometry in a biological sample the variation in intensity of at least one of the peaks (m/z) ± 0.3% selected from the group consisting of 10129 Th, 9749 Th, 10092 Th, 7935 Th, 4620 Th, 4748 Th, 8565 Th, 7565 Th, 4518 Th, 7936 Th, 5044 Th, 6699 Th, 11310 Th, 12277 Th, 6805 Th, 6880 Th, 8566 Th, 8309 Th, 5564 Th, 9711 Th, 7263 Th, 10296 Th and 4353 Th and/or of at least one of the peaks (m/z) ± 0.3% selected from the group consisting of 4987 Th, 7110 Th, 4804 Th, 9957 Th, 6719 Th, 4372 Th, 4196 Th, 4111 Th, 4282 Th, 5935 Th and 5519 Th.
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Inventors:
MAGNI FULVIO (IT)
PAGNI FABIO (IT)
CHINELLO CLIZIA (IT)
DE SIO GABRIELE (IT)
PAGNI FABIO (IT)
CHINELLO CLIZIA (IT)
DE SIO GABRIELE (IT)
Application Number:
PCT/IB2016/056171
Publication Date:
May 26, 2017
Filing Date:
October 14, 2016
Export Citation:
Assignee:
UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA (IT)
International Classes:
F25B25/00; G01N33/68
Domestic Patent References:
| WO2014189467A1 | 2014-11-27 | |||
| WO2009111881A1 | 2009-09-17 | |||
| WO2005079410A2 | 2005-09-01 |
Foreign References:
| US20110275065A1 | 2011-11-10 | |||
| US20070087448A1 | 2007-04-19 |
Other References:
F. PAGNI ET AL: "Proteomics for the diagnosis of thyroid lesions: preliminary report", CYTOPATHOLOGY, vol. 26, no. 5, 20 July 2014 (2014-07-20), GB, pages 318 - 324, XP055275833, ISSN: 0956-5507, DOI: 10.1111/cyt.12166
YOUNG JOO PARK ET AL: "Diagnostic Value of Galectin-3, HBME-1, Cytokeratin 19, High Molecular Weight Cytokeratin, Cyclin D1 and p27kip1 in the Differential Diagnosis of Thyroid Nodules", J KOREAN MED SCI, 1 January 2007 (2007-01-01), pages 621 - 628, XP055342058, Retrieved from the Internet [retrieved on 20170203]
KYUENG-WHAN MIN ET AL: "Imaging Mass Spectrometry in Papillary Thyroid Carcinoma for the Identification and Validation of Biomarker Proteins", JOURNAL OF KOREAN MEDICAL SCIENCE, vol. 29, no. 7, 1 January 2014 (2014-01-01), SEOUL, KR, pages 934, XP055341730, ISSN: 1011-8934, DOI: 10.3346/jkms.2014.29.7.934
JANETE M. CERUTTI ET AL: "A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression", JOURNAL OF CLINICAL INVESTIGATION, vol. 113, no. 8, 15 April 2004 (2004-04-15), pages 1234 - 1242, XP055042033, ISSN: 0021-9738, DOI: 10.1172/JCI200419617
LEANDRO LUONGO DE MATOS ET AL: "Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis", DIAGNOSTIC PATHOLOGY, vol. 7, no. 1, 13 August 2012 (2012-08-13), BIOMED CENTRAL LTD, LO, pages 97, XP021129551, ISSN: 1746-1596, DOI: 10.1186/1746-1596-7-97
CATHERINE B BARDEN ET AL: "Classification of Follicular Thyroid Tumors by Molecular Signature: Results of Gene Profiling 1 Departments of Surgery [", CLINICAL CANCER RESEARCH, 1 May 2003 (2003-05-01), XP055341955, Retrieved from the Internet [retrieved on 20170203]
PAGNI FABIO ET AL: "Proteomics in thyroid cytopathology: Relevance of MALDI-imaging in distinguishing malignant from benign lesions.", PROTEOMICS, vol. 16, no. 11-12, June 2016 (2016-06-01), pages 1775 - 1784, XP002766750, ISSN: 1615-9861, DOI: 10.1002/pmic.201500448
YOUNG JOO PARK ET AL: "Diagnostic Value of Galectin-3, HBME-1, Cytokeratin 19, High Molecular Weight Cytokeratin, Cyclin D1 and p27kip1 in the Differential Diagnosis of Thyroid Nodules", J KOREAN MED SCI, 1 January 2007 (2007-01-01), pages 621 - 628, XP055342058, Retrieved from the Internet
KYUENG-WHAN MIN ET AL: "Imaging Mass Spectrometry in Papillary Thyroid Carcinoma for the Identification and Validation of Biomarker Proteins", JOURNAL OF KOREAN MEDICAL SCIENCE, vol. 29, no. 7, 1 January 2014 (2014-01-01), SEOUL, KR, pages 934, XP055341730, ISSN: 1011-8934, DOI: 10.3346/jkms.2014.29.7.934
JANETE M. CERUTTI ET AL: "A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression", JOURNAL OF CLINICAL INVESTIGATION, vol. 113, no. 8, 15 April 2004 (2004-04-15), pages 1234 - 1242, XP055042033, ISSN: 0021-9738, DOI: 10.1172/JCI200419617
LEANDRO LUONGO DE MATOS ET AL: "Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis", DIAGNOSTIC PATHOLOGY, vol. 7, no. 1, 13 August 2012 (2012-08-13), BIOMED CENTRAL LTD, LO, pages 97, XP021129551, ISSN: 1746-1596, DOI: 10.1186/1746-1596-7-97
CATHERINE B BARDEN ET AL: "Classification of Follicular Thyroid Tumors by Molecular Signature: Results of Gene Profiling 1 Departments of Surgery [", CLINICAL CANCER RESEARCH, 1 May 2003 (2003-05-01), XP055341955, Retrieved from the Internet
PAGNI FABIO ET AL: "Proteomics in thyroid cytopathology: Relevance of MALDI-imaging in distinguishing malignant from benign lesions.", PROTEOMICS, vol. 16, no. 11-12, June 2016 (2016-06-01), pages 1775 - 1784, XP002766750, ISSN: 1615-9861, DOI: 10.1002/pmic.201500448
Attorney, Agent or Firm:
BOSIA, Alessandra et al. (IT)
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