METHOD FOR IN VITRO SELECTION OF 2'-SUBSTITUTED NUCLEIC ACIDS

Title:

METHOD FOR IN VITRO SELECTION OF 2'-SUBSTITUTED NUCLEIC ACIDS

Document Type and Number:

WIPO Patent Application WO2005010150

Kind Code:

A3

Abstract:

Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence. The aptamers produced by the methods of the invention have increased stability and half life.

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Inventors:

KEEFE ANTHONY D (US)
WILSON CHARLES (US)
BURMEISTER PAULA (US)
KEENE SARA CHESWORTH (US)

Application Number:

PCT/US2004/020162

Publication Date:

April 27, 2006

Filing Date:

June 22, 2004

Export Citation:

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Assignee:

ARCHEMIX CORP (US)
KEEFE ANTHONY D (US)
WILSON CHARLES (US)
BURMEISTER PAULA (US)
KEENE SARA CHESWORTH (US)

International Classes:

C12P19/34; C12Q1/68; C12N; (IPC1-7): C12Q1/68; C12P19/34; C07H21/02

Foreign References:

US5660985A	1997-08-26
US6107037A	2000-08-22

Other References:

BRIEBA L.G. ET AL: "Roles of histidine 784 and tyrosine 639 in ribose discrimination by T7 RNA polymerase", BIOCHEMISTRY, vol. 39, 2000, pages 919 - 923, XP002977781

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