METHOD FOR INCREASING ACTIVITY IN HUMAN STEM CELL

WIPO Patent Application WO/2011/126264

A2

Provided are a method for preparing a highly active human mesenchymal stem cell, which includes forming a spherical cell aggregate by cultivating human mesenchymal stem cells against gravity; a highly active stem cell aggregate prepared thereby; a cell theraputic including the stem cell aggregate; and a method for forming a spherical cell aggregate by cultivating human mesenchymal stem cells, wherein the amount of E-cadherin in the mesenchymal stem cell is increased during the cultivation.

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KIM HYO-SOO (KR)
KANG HYUN-JAE (KR)
LEE EUN-JU (KR)

PCT/KR2011/002358

October 13, 2011

April 05, 2011

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SEOUL NAT UNIV HOSPITAL (KR)
KIM HYO-SOO (KR)
KANG HYUN-JAE (KR)
LEE EUN-JU (KR)

C12N5/0775; A61K35/12; A61P9/00; A61P19/00; A61P37/00; C12N5/02

KR20100012153A

2010-02-08

THOMSON ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
REUBINOFF ET AL., NAT. BIOTECHNOL., vol. 18, 2000, pages 399 - 404
PINEDA ET AL., ACTA ANAT, 1992
WAKITANI ET AL., J BONE JOINT SURG AM, 1994
VARET J. ET AL., AM J PHYSIOL LUNG CELL MOL PHYSIOL, vol. 298, 2010, pages L768 - L774
KUHN H ET AL., RESPIROLOGY, vol. 15, 2010, pages 343 - 348

FIRSTLAW LEE & KO (275-7 Yangjae-Dong Seocho-Ku, Seoul 137-739, KR)

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