Title:
METHOD OF INCREASING THE HYDRODYNAMIC VOLUME OF POLYPEPTIDES BY ATTACHING TO GONADOTROPHIN CARBOXY TERMINAL PEPTIDES
Document Type and Number:
WIPO Patent Application WO/2014/080401
Kind Code:
A3
Abstract:
This invention is directed to the use of a chorionic gonadotrophin carboxy terminal peptide (CTP) or fragments thereof for modifying a polypeptide or a fragment thereof in order to increase the hydrodynamic volume of the polypeptide or fragment thereof. Biotechnology products cover an increased proportion of all therapeutic drugs, including monoclonal antibodies, vaccines, growth factors, hormones, cytokines, coagulation factors, fusion proteins, enzymes and other proteins.
Inventors:
HERSHKOVITZ OREN (IL)
BAR-ILAN AHUVA (IL)
BAR-ILAN AHUVA (IL)
Application Number:
PCT/IL2013/050960
Publication Date:
September 25, 2014
Filing Date:
November 20, 2013
Export Citation:
Assignee:
OPKO BIOLOG LTD (IL)
International Classes:
C07K14/47
Foreign References:
| US20070184530A1 | 2007-08-09 |
Other References:
KONTERMANN.: "Strategies for extended serum half-life of protein therapeutics''.", CURRENT OPINION IN BIOTECHNOLOGY, vol. 22, 20 August 2011 (2011-08-20), pages 868 - 876, XP028397475
KANDA ET AL.: "Genetic Fusion of an a-Subunit Gene to the Follicle-Stimulating Hormone and Chorionic Gonadotropin-b Subunit Genes: Production of a Bifunctional Protein'' .", MOLECULAR ENDOCRINOLOGY, vol. 13, no. 11, November 1999 (1999-11-01), pages 1873 - 1881, XP000872232
KESSLER ET AL.: "Structure and location of the O-glycosidic carbohydrate units of human chorionic gonadotropin''.", THE JOUMAL OF BIOLOGICAL CHEMISTRY., vol. 254, no. 16, 25 August 1979 (1979-08-25), pages 7909 - 7914, XP002563495
KANDA ET AL.: "Genetic Fusion of an a-Subunit Gene to the Follicle-Stimulating Hormone and Chorionic Gonadotropin-b Subunit Genes: Production of a Bifunctional Protein'' .", MOLECULAR ENDOCRINOLOGY, vol. 13, no. 11, November 1999 (1999-11-01), pages 1873 - 1881, XP000872232
KESSLER ET AL.: "Structure and location of the O-glycosidic carbohydrate units of human chorionic gonadotropin''.", THE JOUMAL OF BIOLOGICAL CHEMISTRY., vol. 254, no. 16, 25 August 1979 (1979-08-25), pages 7909 - 7914, XP002563495
Attorney, Agent or Firm:
SCHINDLER, Yaffa et al. (5 Shenkar StreetP.O. Box, 46733 Herzlia, IL)
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