Title:
METHOD FOR INCREASING STEM CELL ACTIVITY AND STEM CELLS PRODUCED THEREBY
Document Type and Number:
WIPO Patent Application WO/2011/129607
Kind Code:
A3
Abstract:
Disclosed is a method for increasing the activity of human stem cells. The method is characterized by treating a culture medium with endothelin-1. Also, the highly active human stem cells prepared by the method and cell therapeutics comprising the highly active human stem cells are provided. Human mesenchymal stem cells of various origins can be activated by the method, and thus resulting highly active human mesenchymal stem cells can be developed as effective cell therapeutics.
Inventors:
KIM HYO-SOO (KR)
LEE EUN-JU (KR)
KANG HYUN-JAE (KR)
LEE EUN-JU (KR)
KANG HYUN-JAE (KR)
Application Number:
PCT/KR2011/002622
Publication Date:
March 08, 2012
Filing Date:
April 13, 2011
Export Citation:
Assignee:
SEOUL NAT UNIV HOSPITAL (KR)
KIM HYO-SOO (KR)
LEE EUN-JU (KR)
KANG HYUN-JAE (KR)
KIM HYO-SOO (KR)
LEE EUN-JU (KR)
KANG HYUN-JAE (KR)
International Classes:
C12N5/0775; A61K35/28; A63C17/02; A63C17/22
Foreign References:
| KR100908481B1 | 2009-07-21 | |||
| KR20100012153A | 2010-02-08 | |||
| US20090035257A1 | 2009-02-05 | |||
| EP2123747A1 | 2009-11-25 | |||
| KR20110115688A | 2011-10-24 |
Other References:
AU ET AL.: "Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature", BLOOD, vol. 111, 6 February 2008 (2008-02-06), pages 4554 - 4558
Attorney, Agent or Firm:
ERUUM PATENT & LAW FIRM (1005-8Daechi-dong, Kangnam-gu, Seoul 135-851, KR)
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