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Title:
METHOD FOR INDUCING DIFFERENTIATION OF INTERMEDIATE MESODERMAL CELL TO RENAL PROGENITOR CELL, AND METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELL TO RENAL PROGENITOR CELL
Document Type and Number:
WIPO Patent Application WO/2018/216743
Kind Code:
A1
Abstract:
A method for producing renal progenitor cells from pluripotent stem cells, comprising steps (i) to (vi): (i) culturing the pluripotent stem cells in a culture medium containing FGF2, BMP4, a GSK-3β inhibitor and retinoic acid or a derivative thereof; (ii) culturing cells produced in step (i) in a culture medium containing FGF2, a GSK-3β inhibitor and BMP7; (iii) culturing cells produced in step (ii) in a culture medium containing FGF2, a GSK-3β inhibitor, BMP7 and a TGFβ inhibitor; (iv) culturing cells produced in step (iii) in a culture medium containing FGF2, a GSK-3β inhibitor, BMP7, activin and a ROCK (Rho-kinase) inhibitor; (v) culturing cells produced in step (iv) in a culture medium containing retinoic acid or a derivative thereof and FGF9; and (vi) culturing cells produced in step (v) in a culture medium containing a GSK-3β inhibitor and FGF9 to induce renal progenitor cells from intermediate mesodermal cells.

Inventors:
SUETA SHINICHI (JP)
KASAHARA TOMOKO (JP)
OSAFUNE KENJI (JP)
Application Number:
PCT/JP2018/019886
Publication Date:
November 29, 2018
Filing Date:
May 23, 2018
Export Citation:
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Assignee:
UNIV KYOTO (JP)
International Classes:
C12N5/0735; A61K35/22; A61L27/38; A61P13/12; C12N5/071; C12N5/10; C12N15/09
Domestic Patent References:
WO2016094948A12016-06-23
WO2015056756A12015-04-23
WO2017049243A12017-03-23
WO2017043666A12017-03-16
WO2014200115A12014-12-18
WO2012011610A12012-01-26
WO2011043405A12011-04-14
WO2007069666A12007-06-21
WO2008118820A22008-10-02
WO2009007852A22009-01-15
WO2009032194A12009-03-12
WO2009058413A12009-05-07
WO2009057831A12009-05-07
WO2009075119A12009-06-18
WO2009079007A12009-06-25
WO2009091659A22009-07-23
WO2009101084A12009-08-20
WO2009101407A22009-08-20
WO2009102983A22009-08-20
WO2009114949A12009-09-24
WO2009117439A22009-09-24
WO2009126250A22009-10-15
WO2009126251A22009-10-15
WO2009126655A22009-10-15
WO2009157593A12009-12-30
WO2010009015A22010-01-21
WO2010033906A22010-03-25
WO2010033920A22010-03-25
WO2010042800A12010-04-15
WO2010050626A12010-05-06
WO2010056831A22010-05-20
WO2010068955A22010-06-17
WO2010098419A12010-09-02
WO2010102267A22010-09-10
WO2010111409A22010-09-30
WO2010111422A22010-09-30
WO2010115050A22010-10-07
WO2010124290A22010-10-28
WO2010147395A22010-12-23
WO2010147612A12010-12-23
WO2009146408A12009-12-03
WO2003062227A12003-07-31
WO2003059913A12003-07-24
WO2003062225A12003-07-31
WO2002076976A22002-10-03
WO2004039796A12004-05-13
Foreign References:
JP2016527878A2016-09-15
JP2015500630A2015-01-08
US20050209261A12005-09-22
US20050192304A12005-09-01
US20040014755A12004-01-22
US20040002508A12004-01-01
US20040002507A12004-01-01
US20030125344A12003-07-03
US20030087919A12003-05-08
Other References:
TOYO HARA T. ET AL.: "Cell Therapy Using Human Induced Pluripotent Stem Cell -Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice", STEM CELLS TRANSLATIONAL MEDICINE, vol. 4, 2015, pages 980 - 992, XP055518813, DOI: doi:10.5966/sctm.2014-0219
TAKASATO M. ET AL.: "A strategy for generating kidney organoids: Recapitulating the development in human pluripotent stem cells", DEVELOPMENTAL BIOLOGY, vol. 420, 2016, pages 210 - 220, XP029838620
OSAFUNE K. ET AL., DEVELOPMENT, vol. 133, 2006, pages 151 - 61
KOBAYASHI A. ET AL., CELL STEM CELL, vol. 3, 2008, pages 132 - 135
TAGUCHI A. ET AL., CELL STEM CELL, vol. 14, 2014, pages 53 - 67
TAKASATO M. ET AL., NAT CELL BIOL., vol. 16, 2014, pages 118 - 26
TAKASATO M. ET AL., NATURE, vol. 526, 2015, pages 564 - 568
MORIZANE R. ET AL., NAT. BIOTECHNOL., vol. 33, 2015, pages 1193 - 1200
BIOCHEM BIOPHYS RES COMMUN., vol. 393, 2010, pages 877 - 82
NAT COMMUN., vol. 4, 2013, pages 1367
NAT COMMUN, vol. 4, 2013, pages 1367
NAT BIOTECHNOL, vol. 28, 2010, pages 611 - 615
EMBO J., vol. 3, 1984, pages 1463 - 1468
J. CELL BIOL., vol. 105, 1987, pages 589 - 598
NATURE, vol. 453, 2008, pages 519 - 523
HUANGFU D ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 1269 - 1275
EMINLI S ET AL., STEM CELLS., vol. 26, 2008, pages 2467 - 2474
FENG B ET AL., NAT. CELL BIOL., vol. 11, 2009, pages 197 - 203
R. L. JUDSON ET AL., NAT. BIOTECHNOL., vol. 27, 2009, pages 459 - 461
LYSSIOTIS CA ET AL., PROC NATL ACAD SCI U S A., vol. 106, 2009, pages 8912 - 8917
KIM JB ET AL., NATURE, vol. 461, 2009, pages 649 - 643
ICHIDA JK ET AL., CELL STEM CELL, vol. 5, 2009, pages 491 - 503
HENG JC ET AL., CELL STEM CELL, vol. 6, 2010, pages 167 - 74
HAN J ET AL., NATURE, vol. 463, 2010, pages 1096 - 100
MALI P ET AL., STEM CELLS, vol. 28, 2010, pages 713 - 720
MAEKAWA M ET AL., NATURE, vol. 474, 2011, pages 225 - 9
TAMURA K ET AL., CELL DIFFER. DEV., vol. 32, 1990, pages 17 - 26
STRICKLAND S ET AL., CANCER RES., vol. 43, 1983, pages 5268 - 5272
TANENAGA, K. ET AL., CANCER RES., vol. 40, 1980, pages 914 - 919
R. K. LINDEMANN ET AL., MOL. CANCER, vol. 2, 2003, pages 20
ISHIZAKI ET AL., MOL. PHARMACOL., vol. 57, 2000, pages 976 - 983
NARUMIYA ET AL., METHODS ENZYMOL., vol. 325, 2000, pages 273 - 284
UENATA ET AL., NATURE, vol. 389, 1997, pages 990 - 994
SASAKI ET AL., PHARMACOL. THER., vol. 93, 2002, pages 225 - 232
NAKAJIMA ET AL., CANCER CHEMOTHER PHARMACOL., vol. 52, no. 4, 2003, pages 319 - 324
P. B. YU ET AL., CIRCULATION, vol. 116, 2007, pages 11 - 60
P. B. YU ET AL., NAT. CHEM. BIOL., vol. 4, 2008, pages 33 - 41
J. HAO ET AL., PLOS ONE, vol. 3, no. 8, 2008, pages e2904
DEV CELL, vol. 23, no. 3, 11 September 2012 (2012-09-11), pages 637 - 651
See also references of EP 3633026A4
Attorney, Agent or Firm:
SANUKI, Shinichi et al. (JP)
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