Title:
METHOD OF INDUCING THE DIFFERENTIATION OF MESENCHYMAL STEM CELL INTO ODONTOBLAST CELL
Document Type and Number:
WIPO Patent Application WO/2006/009291
Kind Code:
A1
Abstract:
It is intended to provide a method of inducing the differentiation of mesenchymal stem cells into odontoblast cells. Namely, a method of producing odontoblast cells from mesenchymal stem cells which comprises culturing the mesenchymal stem cells in the presence of a factor inducing a receptor of a differentiation factor toward odontoblast cells and a differentiation-inducing factor capable of inducing the differentiation into odontoblast cells to thereby differentiate the mesenchymal stem cells into odontoblast cells.
Inventors:
IESHIMA DAISUKE (JP)
ANDO YUSUKE (JP)
KAGAMI HIDEAKI (JP)
UEDA MINORU (JP)
ANDO YUSUKE (JP)
KAGAMI HIDEAKI (JP)
UEDA MINORU (JP)
Application Number:
PCT/JP2005/013679
Publication Date:
January 26, 2006
Filing Date:
July 20, 2005
Export Citation:
Assignee:
HITACHI MEDICAL CORP (JP)
UNIV NAGOYA NAT UNIV CORP (JP)
IESHIMA DAISUKE (JP)
ANDO YUSUKE (JP)
KAGAMI HIDEAKI (JP)
UEDA MINORU (JP)
UNIV NAGOYA NAT UNIV CORP (JP)
IESHIMA DAISUKE (JP)
ANDO YUSUKE (JP)
KAGAMI HIDEAKI (JP)
UEDA MINORU (JP)
International Classes:
A61K35/32; A61P1/02; C12N5/00; C12N5/077; C12N5/0775; C12N15/09
Domestic Patent References:
| WO2003066840A2 | 2003-08-14 |
Foreign References:
| JP2004504052A | 2004-02-12 | |||
| JP2004201612A | 2004-07-22 |
Other References:
SHIBA H ET AL: "Macrophage inflammatory protein-3alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 306, 2003, pages 867 - 871, XP004432100
GRONTHOS S ET AL: "Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.", PROC NATL ACAD SCI USA., vol. 97, no. 25, 5 December 2000 (2000-12-05), pages 13625 - 13630, XP002201506
IEJIMA DAISUKE ET AL: "Kan'yokei Kansaibo kara Shihai Kosei Saibo eno Bunka Yudoho ni Kansuru Kento.", J ORAL BIOSCI., vol. 46, 1 September 2004 (2004-09-01), pages 140, (290-2P), XP002998925
GRONTHOS S ET AL: "Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.", PROC NATL ACAD SCI USA., vol. 97, no. 25, 5 December 2000 (2000-12-05), pages 13625 - 13630, XP002201506
IEJIMA DAISUKE ET AL: "Kan'yokei Kansaibo kara Shihai Kosei Saibo eno Bunka Yudoho ni Kansuru Kento.", J ORAL BIOSCI., vol. 46, 1 September 2004 (2004-09-01), pages 140, (290-2P), XP002998925
Attorney, Agent or Firm:
SIKs & Co. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo 31, JP)
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