Title:
METHOD OF INHIBITING DEGRADING PROTEASE ACTIVITY IN AGING
Document Type and Number:
WIPO Patent Application WO/2023/141125
Kind Code:
A3
Abstract:
Provided herein are methods of reversing accumulation of a serine protease, reversing cellular damage, and/or preserving extracellular matrix in an organ of a subject comprising selecting a subject at risk of damage to the organ, and administering a therapeutically effective amount of a serine protease inhibitor. The serine protease inhibitor may be an orally administered competitive inhibitor.
Inventors:
SCHMID-SCHOENBEIN GEERT (US)
DELANO FRANK A (US)
DELANO FRANK A (US)
Application Number:
PCT/US2023/010998
Publication Date:
August 31, 2023
Filing Date:
January 18, 2023
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
A61K38/57; A23K20/189; A61P25/00
Foreign References:
| US20190183989A1 | 2019-06-20 | |||
| US20140286954A1 | 2014-09-25 | |||
| US20170231935A1 | 2017-08-17 |
Other References:
CHATRE LAURENT, BIARD DENIS S. F., SARASIN ALAIN, RICCHETTI MIRIA: "Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 112, no. 22, 2 June 2015 (2015-06-02), XP093087706, ISSN: 0027-8424, DOI: 10.1073/pnas.1422264112
Attorney, Agent or Firm:
GREY, Kathryn et al. (US)
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