METHOD FOR INHIBITING HIV REPLICATION IN MAMMAL AND HUMAN CELLS

Title:

METHOD FOR INHIBITING HIV REPLICATION IN MAMMAL AND HUMAN CELLS

Document Type and Number:

WIPO Patent Application WO/2011/120474

Kind Code:

A9

Abstract:

The invention relates to a method for inhibiting the replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, specifically the proteins that form part of the cytoskeletal intermediate filaments, and more specifically the proteins vimentin and/or keratin-10. Intervening in the structure of said proteins inhibits replication of the virus in human cells. The invention likewise relates to the use of agents, which include peptides and/or interfering RNA and/or lipid compounds, and negatively modulates or alters the cell cytoskeleton, in order to prevent or treat HIV infection. The invention provides the means and methods for altering the structure of the cell cytoskeleton/filament, which disrupts the HIV infection in human cells; the virus can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin-10 (for example, by interfering RNA transcription control) or by using peptides that alter the cytoskeleton.

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Inventors:

FERNANDEZ ORTEGA CELIA BERTA (CU)
RAMIREZ SUAREZ ANNA CARIDYS (CU)
CASILLAS CASANOVA DIONNE (CU)
PANEQUE GUERRERO TAIMI EMELIA (CU)
UBIETA GOMEZ RAIMUNDO (CU)
DUBED ECHEVARRIA MARTA (CU)
NAVEA LEYVA LEONOR MARGARITA (CU)
CASTELLANOS SERRA LILA ROSA (CU)
DUARTE CANO CARLOS ANTONIO (CU)
FALCON CAMA VIVIANA (CU)
REYES ACOSTA OSVALDO (CU)

Application Number:

PCT/CU2011/000001

Publication Date:

March 22, 2012

Filing Date:

April 01, 2011

Export Citation:

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Assignee:

CT INGENIERIA GENETICA BIOTECH (CU)
FERNANDEZ ORTEGA CELIA BERTA (CU)
RAMIREZ SUAREZ ANNA CARIDYS (CU)
CASILLAS CASANOVA DIONNE (CU)
PANEQUE GUERRERO TAIMI EMELIA (CU)
UBIETA GOMEZ RAIMUNDO (CU)
DUBED ECHEVARRIA MARTA (CU)
NAVEA LEYVA LEONOR MARGARITA (CU)
CASTELLANOS SERRA LILA ROSA (CU)
DUARTE CANO CARLOS ANTONIO (CU)
FALCON CAMA VIVIANA (CU)
REYES ACOSTA OSVALDO (CU)

International Classes:

C07K14/47; A61K31/5575; A61K31/7105; A61K38/17; A61P31/18; C07C405/00; C12N15/113

Attorney, Agent or Firm:

GONZÁLEZ BLANCO, Sonia (Avenida 31 entre 158 y 190,Cubanacá, Playa La Habana, CU)

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