Title:
METHOD FOR INHIBITING THE INDUCTION OF CELL DEATH BY INHIBITING THE SYNTHESIS OR SECRETION OF AGE-ALBUMIN IN CELLS OF THE MONONUCLEAR PHAGOCYTE SYSTEM
Document Type and Number:
WIPO Patent Application WO/2011/142545
Kind Code:
A3
Abstract:
The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death. Therefore, the AGE-albumin synthesis inhibitor of the present invention can be valuably used in the diagnosis or treatment of degenerative diseases or autoimmune diseases such as Alzheimer's disease, strokes, Parkinson's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, diabetic retinopathy, AIDS, aging, pulmonary fibrosis, spinal cord injuries, etc.
Inventors:
LEE BONG HEE (KR)
BYUN KYUNG HEE (KR)
BYUN KYUNG HEE (KR)
Application Number:
PCT/KR2011/003147
Publication Date:
April 05, 2012
Filing Date:
April 28, 2011
Export Citation:
Assignee:
GACHON UNIVERSITY OF MEDICINE SCIENCE INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR)
LEE BONG HEE (KR)
BYUN KYUNG HEE (KR)
LEE BONG HEE (KR)
BYUN KYUNG HEE (KR)
International Classes:
C12N5/0786; A61P25/00; C07K16/18; C12N5/02; C12N15/113
Other References:
DUKIC-SKTEFANOVIC, S ET AL.: "AGES in Brain Ageing: AGE-Inhibitors as Neuroprotective and Anti-Dementia Drugs?", BIOGERONTOLOGY, vol. 2, 2001, pages 19 - 34
AHN, S-M. ET AL.: "Human Microglial Cells Synthesize Albumin in Brain", PLOS ONE, vol. 3, no. ISS.7, 30 July 2008 (2008-07-30), pages E2829
SYMMETREL(R): "Amantadine Hydrochloride, USP", TABLETS AND SYRUP, January 2009 (2009-01-01), pages 1 - 15
STRAND, V. ET AL.: "Treatment of Active Rheumatoid Arthritis With Leflunomide Compared With Placebo and Methotrexate", ARCH INTERN MED, vol. 159, 22 November 1999 (1999-11-22), pages 2542 - 2550
CAMERON, N.E. ET AL.: "Inhibitors of Advanced Glycation End Product Formation and Neurovascular Dysfunction in Experimental Diabetes", ANN, N.Y. ACAD. SCI., vol. 1043, 2005, pages 784 - 792
AHN, S-M. ET AL.: "Human Microglial Cells Synthesize Albumin in Brain", PLOS ONE, vol. 3, no. ISS.7, 30 July 2008 (2008-07-30), pages E2829
SYMMETREL(R): "Amantadine Hydrochloride, USP", TABLETS AND SYRUP, January 2009 (2009-01-01), pages 1 - 15
STRAND, V. ET AL.: "Treatment of Active Rheumatoid Arthritis With Leflunomide Compared With Placebo and Methotrexate", ARCH INTERN MED, vol. 159, 22 November 1999 (1999-11-22), pages 2542 - 2550
CAMERON, N.E. ET AL.: "Inhibitors of Advanced Glycation End Product Formation and Neurovascular Dysfunction in Experimental Diabetes", ANN, N.Y. ACAD. SCI., vol. 1043, 2005, pages 784 - 792
Attorney, Agent or Firm:
ERUUM PATENT & LAW FRIM (1005-8,Daechi-dong, Kangnam-gu, Seoul 135-851, KR)
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