Title:
METHOD OF INHIBITING POSTISCHEMIC REPERFUSION-INDUCED CELL DEATH AND CELL DEATH INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2006/011273
Kind Code:
A1
Abstract:
It is intended to provide a method of preventing or relieving reperfusion-induced cell death (apoptotic cell death) of cardiomyocytes due to postischemic reperfusion; a reperfusion-induced cell death (apoptotic cardiomyocyte death) inhibitor; and a therapeutic drug or a preventive drug for diseases caused by reperfusion-induced cell death (apoptotic cell death) which contains the reperfusion-induced cell death inhibitor. Namely, reperfusion-induced cell death (apoptotic cell death) can be significantly inhibited by administering a VSOR Cl channel blocker or an ROS scavenger to cardoimyocytes, which have been subjected to an ischemic treatment, during reperfusion. As the VSOR Cl channel blocker, it is preferable to use, for example, DIDS or NPPB. As the ROS scavenger, it is preferable to use, for example, Tiron, catalase or NAC. Thus, various diseases caused by reperfusion-induced cell death can be effectively treated or prevented.
Inventors:
Okada, Yasunobu
Takahashi, Nobuyuki
Takahashi, Nobuyuki
Application Number:
PCT/JP2005/007479
Publication Date:
February 02, 2006
Filing Date:
April 19, 2005
Export Citation:
Assignee:
JAPAN SCIENCE AND TECHNOLOGY AGENCY (1-8 Hon-cho 4-chome, Kawaguchi-shi Saitama, 12, 33200, JP)
NATIONAL INSTITUTES OF NATURAL SCIENCES (21-1, Osawa 2-chome Mitaka-sh, Tokyo 88, 18185, JP)
Okada, Yasunobu
Takahashi, Nobuyuki
NATIONAL INSTITUTES OF NATURAL SCIENCES (21-1, Osawa 2-chome Mitaka-sh, Tokyo 88, 18185, JP)
Okada, Yasunobu
Takahashi, Nobuyuki
International Classes:
A61K31/185; A61K31/198; A61K31/245; A61K31/26; A61K38/43; A61K45/00; A61P25/16; A61P25/28; A61P43/00; A61P9/00; A61P9/04; A61P9/10; C12Q1/02; C12Q1/37; C12Q1/68; G01N33/15; G01N33/50; (IPC1-7): C12Q1/02; A61K31/185; A61K31/198; A61K31/245; A61K31/26; A61K38/43; A61K45/00; A61P9/00; A61P9/04; A61P9/10; A61P25/16; A61P25/28; A61P43/00; C12Q1/37; C12Q1/68; G01N33/15; G01N33/50
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (Daiwa Minamimorimachi Building, 2-6 Tenjinbashi 2-chome Kita, Kita-k, Osaka-shi Osaka, 530-0041, JP)