Title:
METHOD OF INHIBITING RESTENOSIS
Document Type and Number:
WIPO Patent Application WO2003089568
Kind Code:
A3
Abstract:
A method of treating or preventing restenosis by administering to an individual an effective amount of an active compound which depletes and/or inhibits blood monocytes or macrophages thereby treating restenosis. A method of inhibiting the activity or production of cytokines or growth factors associated with vascular restenosis, by administering to an individual an effective amount of an active compound which depletes and/or inhibits blood monocytes or macrophages thereby treating restenosis. The cytokines and growth factors include, but are not limited to interleukin 1-beta, matrix metalloproteinase-2, and platelet-derived growth factor beta (PDGFbeta). The active compound may be administered directly, encapsulated in a carrier particle, or in a particulate dosage form. The compound may be encapsulated, embedded or adsorbed within the particle, dispersed uniformly in the polymer matrix, adsorbed on the particle surface, or in combination of any of these forms. The particles include liposomes or inert polymeric particles, such as microcapsules, nanocapsules, nanoparticles, nanospheres, or microparticles. The particulates include any suspended or dispersed form of the compound which is not encapsulated, entrapped, or adsorbed within a polymeric particle. The particulates include suspended or dispersed colloids, aggregates, flocculates, insoluble salts and insoluble complexes of the active compound. The compound includes any intra-cellular toxin which depletes and/or inhibits blood monocytes or macrophages, such as, for example, a bisphosphonate.
Inventors:
GOLOMB GERSHON (IL)
DANENBERG HAIM (US)
DANENBERG HAIM (US)
Application Number:
PCT/IB2003/001437
Publication Date:
December 24, 2003
Filing Date:
April 16, 2003
Export Citation:
Assignee:
YISSUM RES DEV CO (IL)
GOLOMB GERSHON (IL)
DANENBERG HAIM (US)
GOLOMB GERSHON (IL)
DANENBERG HAIM (US)
International Classes:
A61K9/00; A61K9/10; A61K9/127; A61K9/14; A61K9/51; A61K31/00; A61K31/66; A61K31/663; A61K33/242; A61K45/00; A61K47/02; (IPC1-7): A61K9/127; A61K9/14; A61K9/916; A61F13/00; A01N65/00; A01N57/00
Domestic Patent References:
| WO1997043437A2 | 1997-11-20 |
Foreign References:
| US5760030A | 1998-06-02 |
Other References:
MONKKONEN ET AL.: "Studies on liposome formulations for intra-articular delivery of clodronate", JOURNAL OF CONTROLLED RELEASE, vol. 35, February 1995 (1995-02-01), pages 145 - 154, XP000516825
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