Title:
METHOD AND INTERMEDIATE FOR PREPARING TULATHROMYCIN
Document Type and Number:
WIPO Patent Application WO/2017/124222
Kind Code:
A1
Abstract:
Disclosed are a method and an intermediate for preparing a tulathromycin. The method comprises the following step: in an organic solvent, subjecting a compound represented by formula (II) and an n-propylamine to a ring-opening addition shown below to obtain a tulathromycin represented by formula (I), wherein the organic solvent is a 1,2-propandiol. The tulathromycin obtained using the method has a high purity, with an HPLC purity being 95% and above, and up to 99% and above, satisfying a required purity for preparing a tulathromycin as a pharmaceutical formulation. The method has a high yield, is simple to operate, and is more suitable for industrial production.
Inventors:
YIN MINGXING (CN)
WU DONGDONG (CN)
WEN WEIJIANG (CN)
WU DONGDONG (CN)
WEN WEIJIANG (CN)
Application Number:
PCT/CN2016/071198
Publication Date:
July 27, 2017
Filing Date:
January 18, 2016
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
International Classes:
C07H17/00; C07H1/00; C07H17/08
Foreign References:
| CN103641869A | 2014-03-19 | |||
| CN102295672A | 2011-12-28 | |||
| CN102786569A | 2012-11-21 | |||
| CN102260306A | 2011-11-30 |
Other References:
See also references of EP 3406619A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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