Title:
METHOD FOR ISOLATING ANTIGEN MOLECULE
Document Type and Number:
WIPO Patent Application WO/2024/071008
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method in which an antigen molecule is efficiently isolated from and detected in an antigen-antibody complex in a biological specimen. Provided is a method which isolates an antigen molecule from a liquid specimen containing an antigen-antibody complex, and involves a binding step for adding the liquid specimen to a column to which an antibody-binding protein is affixed, and binding an antibody molecule in the antigen-antibody complex to the antibody-binding protein, and an elution step for eluting an eluate which includes the antigen molecule by separating the antigen molecule in the antigen-antibody complex from the antibody molecule, wherein said elution step involves continuously or incrementally decreasing the pH of the buffer solution while adding the buffer solution to the column.
Inventors:
TAGUCHI AYUMU (JP)
ABE YUICHI (JP)
OKUMOTO YASUHIDE (JP)
ABE YUICHI (JP)
OKUMOTO YASUHIDE (JP)
Application Number:
PCT/JP2023/034650
Publication Date:
April 04, 2024
Filing Date:
September 25, 2023
Export Citation:
Assignee:
AICHI PREFECTURE (JP)
International Classes:
G01N33/531; B01J20/281; C07K1/16; C12N7/00; G01N30/34; G01N30/88
Domestic Patent References:
| WO2000020442A1 | 2000-04-13 | |||
| WO2011078332A1 | 2011-06-30 |
Foreign References:
| JP2016538275A | 2016-12-08 | |||
| JPH0772156A | 1995-03-17 | |||
| JP2017070289A | 2017-04-13 |
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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