Title:
METHOD FOR JUDGING ONSET POSSIBILITY OF LARGE BOWEL CANCER
Document Type and Number:
WIPO Patent Application WO/2018/008740
Kind Code:
A1
Abstract:
The present invention provides a method for judging the onset possibility of large bowel cancer in a human ulcerative colitis patient, etc. The method comprises a measurement step for measuring methylation ratios at one or more CpG sites existing in specific differentially methylated regions in DNA collected from a biological sample that is obtained from the human ulcerative colitis patient, and a judgment step for judging the onset possibility of large bowel cancer in the human ulcerative colitis patient on the basis of the average methylation ratio of the differentially methylated regions, said average methylation ratio being calculated from the measured methylation ratios, and preset standard values or a preset multivariable discriminant, wherein: the standard values are values having been set for the methylation ratios in the respective differentially methylated regions for discriminating a cancerous ulcerative colitis patient from a non-cancerous ulcerative colitis patient; and the multivariable discriminant contains, as variables, the average methylation ratios at one or more differentially methylated regions among the specific differentially methylated regions.
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Inventors:
KUSUNOKI MASATO (JP)
TOIYAMA YUJI (JP)
TANAKA KOJI (JP)
ARAKI TOSHIMITSU (JP)
MITSUI AKIRA (JP)
TAKEHANA KENJI (JP)
UMEZAWA TSUTOMU (JP)
TOIYAMA YUJI (JP)
TANAKA KOJI (JP)
ARAKI TOSHIMITSU (JP)
MITSUI AKIRA (JP)
TAKEHANA KENJI (JP)
UMEZAWA TSUTOMU (JP)
Application Number:
PCT/JP2017/024956
Publication Date:
January 11, 2018
Filing Date:
July 07, 2017
Export Citation:
Assignee:
HANUMAT CO LTD (JP)
EA PHARMA CO LTD (JP)
EA PHARMA CO LTD (JP)
International Classes:
C12Q1/68; C12M1/26; C12N15/09; C12N15/11; G01N1/04; G01N33/50
Domestic Patent References:
| WO2015153283A1 | 2015-10-08 | |||
| WO2014026768A1 | 2014-02-20 |
Foreign References:
| JP2015006164A | 2015-01-15 | |||
| JP2014140377A | 2014-08-07 | |||
| JP2003235799A | 2003-08-26 |
Other References:
CHEN, WEI: "Screening for differentially methylated genes among human colorectal cancer tissues and normal mucosa by microarray chip.", MOL. BIOL. REP., vol. 40, no. 5, 2013, pages 3457 - 3464, XP055451736
KIBRIYA, MUHAMMAD G.: "A genome-wide DNA methylation study in colorectal carcinoma", BMC MEDICAL GENOMICS, vol. 4, no. 1, 2011, pages 1 - 16, XP021104259
ANONYMOUS: "13B1X00204MC009: Codman Micro Tweezers", PMDA, 19 June 2009 (2009-06-19), pages 1 - 3, XP009519712, Retrieved from the Internet [retrieved on 20170804]
See also references of EP 3483282A4
KIBRIYA, MUHAMMAD G.: "A genome-wide DNA methylation study in colorectal carcinoma", BMC MEDICAL GENOMICS, vol. 4, no. 1, 2011, pages 1 - 16, XP021104259
ANONYMOUS: "13B1X00204MC009: Codman Micro Tweezers", PMDA, 19 June 2009 (2009-06-19), pages 1 - 3, XP009519712, Retrieved from the Internet
See also references of EP 3483282A4
Attorney, Agent or Firm:
SHIGA Masatake et al. (JP)
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