Title:
METHOD AND KIT FOR SCREENING NOVEL CYCLIC DINUCLEOTIDE RECEPTOR AND AGONIST OR INHIBITOR THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/072048
Kind Code:
A1
Abstract:
Provided is a recombinant vector capable of expressing a novel receptor (STING subtype M) for feeling exogenous cyclic dinucleotide, also provides a method and kit for specifically authenticating and detecting the expression of the receptor, and further provides a model and kit for screening an agonist or inhibitor drug using the new gene STING subtype M as a target spot and an application of the model and the kit. The screening model and kit can simplify screening steps, improve screening efficiency and enlarge the drug screening range.
Inventors:
LIANG NA (CN)
GU SUJIE (CN)
LI XIAOBO (CN)
GU SUJIE (CN)
LI XIAOBO (CN)
Application Number:
PCT/CN2018/103431
Publication Date:
April 18, 2019
Filing Date:
August 31, 2018
Export Citation:
Assignee:
GUANGZHOU WINKEY TECH CO LTD (CN)
International Classes:
C07K14/47; C12N5/10; C12N15/12; C12N15/85; C12Q1/02; C12Q1/6888; G01N33/68
Foreign References:
| CN107619438A | 2018-01-23 | |||
| CN105377867A | 2016-03-02 |
Other References:
DATABASE NUCLEOTIDE 3 October 2017 (2017-10-03), XU, M.M. ET AL.: "Mus Musculus Transmembrane Protein 173 (Tmeml73), Transcript Variant 3, mRNA", XP055591017, retrieved from NCBI Database accession no. NM_001289592
DATABASE NUCLEOTIDE 6 June 2016 (2016-06-06), ANONYMOUS: "Predicted: Homo Sapiens Transmembrane Protein 173 (TMEM173), Transcript Variant X3, mRNA", XP055591048, retrieved from NCBI Database accession no. XM_011537640.2
DATABASE NUCLEOTIDE 6 June 2016 (2016-06-06), ANONYMOUS: "Predicted: Homo Sapiens Transmembrane Protein 173 (TMEM173), Transcript Variant X3, mRNA", XP055591048, retrieved from NCBI Database accession no. XM_011537640.2
ISHIKAWA, H. ET AL.: "STING is an Endoplasmic Reticulum Adaptor that Facilitates Innate Immune Signalling", NATURE, vol. 455, 2 October 2008 (2008-10-02), pages 674 ; 679, XP055021546
BURDETTE, D.L. ET AL.: "STING is a Direct Innate Immune Sensor of Cyclic Di-GMP", NATURE, vol. 478, 27 October 2011 (2011-10-27), pages 515 - 519, XP055453217, ISSN: 0028-0836, DOI: 10.1038/nature10429
XU, M.M. ET AL.: "Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-Priming Through Signal Regulatory Protein a Signaling", IMMUNITY, vol. 47, 15 August 2017 (2017-08-15), pages 363 - 373, XP085176150
DATABASE NUCLEOTIDE 6 June 2016 (2016-06-06), ANONYMOUS: "Predicted: Homo Sapiens Transmembrane Protein 173 (TMEM173), Transcript Variant X3, mRNA", XP055591048, retrieved from NCBI Database accession no. XM_011537640.2
DATABASE NUCLEOTIDE 6 June 2016 (2016-06-06), ANONYMOUS: "Predicted: Homo Sapiens Transmembrane Protein 173 (TMEM173), Transcript Variant X3, mRNA", XP055591048, retrieved from NCBI Database accession no. XM_011537640.2
ISHIKAWA, H. ET AL.: "STING is an Endoplasmic Reticulum Adaptor that Facilitates Innate Immune Signalling", NATURE, vol. 455, 2 October 2008 (2008-10-02), pages 674 ; 679, XP055021546
BURDETTE, D.L. ET AL.: "STING is a Direct Innate Immune Sensor of Cyclic Di-GMP", NATURE, vol. 478, 27 October 2011 (2011-10-27), pages 515 - 519, XP055453217, ISSN: 0028-0836, DOI: 10.1038/nature10429
XU, M.M. ET AL.: "Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-Priming Through Signal Regulatory Protein a Signaling", IMMUNITY, vol. 47, 15 August 2017 (2017-08-15), pages 363 - 373, XP085176150
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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