METHOD OF LABELING SULFENIC ACID-CONTAINING PROTEINS AND PEPTIDES

Title:

METHOD OF LABELING SULFENIC ACID-CONTAINING PROTEINS AND PEPTIDES

Document Type and Number:

WIPO Patent Application WO/2013/039717

Kind Code:

A3

Abstract:

A method of labeling a sulfenic acid (-SOH) group of a cysteine residue in a protein or peptide, comprises contacting said protein or peptide with a beta-ketoester to covalently couple said beta-ketoester to said cysteine residue and form a beta-ketoester-labeled cysteine residue in said protein or peptide.

Inventors:

FURDUI CRISTINA M (US)
TSANG ALLEN W (US)
QIAN JIANG (US)

Application Number:

PCT/US2012/053376

Publication Date:

May 08, 2014

Filing Date:

August 31, 2012

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Assignee:

UNIV WAKE FOREST HEALTH SCIENCES (US)
FURDUI CRISTINA M (US)
TSANG ALLEN W (US)
QIAN JIANG (US)

International Classes:

G01N33/00; G01N24/00

Foreign References:

US20060084173A1

2006-04-20

Other References:

QIAN ET AL.: "A simple and effectvie strategy for labeling cysteine sulfenic acid in proteins by utilization of beta-ketoesters as cleavable probes", CHEM COMMUN, vol. 48, 2012, pages 4091 - 4093

Attorney, Agent or Firm:

MYERS BIGEL SIBLEY & SAJOVEC, P.A. (Raleigh, North Carolina, US)

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