Title:
METHOD FOR LIGHT-INDUCED DECARBOXYLATION COUPLING OF ACTIVE CARBOXYLIC ACID ESTER UNDER NON-METAL CATALYSIS
Document Type and Number:
WIPO Patent Application WO/2020/063399
Kind Code:
A1
Abstract:
Provided is a method for the light-induced decarboxylation coupling of an active carboxylic acid ester under non-metal catalysis, the method comprising the steps of reacting an active carboxylic acid ester compound represented by formula (1), in the presence of an iodide salt, a phosphine ligand, a solvent, and an optional additive, under light irradiation to decarboxylate same, and introducing an azacyclic ring or producing a β-aminoketone, wherein R is: a C1-C30 alkyl group without any functional group, a C1-C30 alkyl group with a functional group, a C6-C30 aryl or heteroaryl group, or a C6-C30 aralkyl group, wherein the functional group is at least one selected from a halogen, an ester group, an ether group, an acyl group, a carbonyl group, a sulfonyl group, a mercapto group, and an amino group, at least one hydrogen atom in the C6-C30 aryl or heteroaryl group and the C6-C30 aralkyl group is optionally substituted with a hydroxyl group, a halogen, a mercapto group, an amido group, a carbonyl group, an ester group, or an ether group, and the heteroatom in the C6-C30 heteroaryl group is at least one selected from nitrogen, oxygen, and sulfur.
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Inventors:
FU YAO (CN)
SHANG RUI (CN)
FU MINGCHEN (CN)
WU YANAN (CN)
WANG JIAXIN (CN)
WANG YATING (CN)
SHANG RUI (CN)
FU MINGCHEN (CN)
WU YANAN (CN)
WANG JIAXIN (CN)
WANG YATING (CN)
Application Number:
PCT/CN2019/106182
Publication Date:
April 02, 2020
Filing Date:
September 17, 2019
Export Citation:
Assignee:
UNIV SCIENCE & TECHNOLOGY CHINA (CN)
International Classes:
C07C269/06; C07C271/18; C07D213/50; C07D213/803; C07D215/12; C07D215/20; C07D215/48
Domestic Patent References:
WO2017046355A1 | 2017-03-23 |
Foreign References:
CN109096150A | 2018-12-28 | |||
CN109134362A | 2019-01-04 | |||
CN109180576A | 2019-01-11 | |||
CN106496114A | 2017-03-15 | |||
CN106699662A | 2017-05-24 |
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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