Title:
METHOD FOR LOCALIZING AND MODIFYING TARGET AMINO ACID GROUP ON MACROMOLECULAR COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/157866
Kind Code:
A1
Abstract:
Provided is a method for localizing and modifying a target amino acid group on a macromolecular compound. The described localization and modification method contains a method for filtering a target amino acid group, which uses a molecule reductive amination reaction to decide a target amino acid group, on the exposed surface of a macromolecular compound, having good solvent accessibility. The described localization and modification method also contains a method for localization and reductive amination of a macromolecular compound, using a modified group having a greater molecular weight and the aforementioned target amino acid group to perform another reductive amination reaction so as to form a modified macromolecular compound having a homogenous load and a localization and modification site.
Inventors:
CHEN SHU-HUI (CN)
HUANG LI-JUAN (CN)
CHOU HO-HSUAN (CN)
HUANG LI-JUAN (CN)
CHOU HO-HSUAN (CN)
Application Number:
PCT/CN2018/077932
Publication Date:
September 07, 2018
Filing Date:
March 02, 2018
Export Citation:
Assignee:
CHEN SHU HUI (CN)
International Classes:
C07K17/08; C07K1/13
Foreign References:
CN105301119A | 2016-02-03 | |||
CN106483294A | 2017-03-08 | |||
CN107478839A | 2017-12-15 | |||
CN1970086A | 2007-05-30 |
Other References:
CHEN, SHUANGNING ET AL.: "Advances in Research on Adenovirus Nanocomplexes for Tumor Therapy", CHINESE JOURNAL OF NEW DRUGS, 31 December 2012 (2012-12-31), pages 378 - 384, ISSN: 1003-3734
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (CN)
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