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Patent Searching and Data


Title:
METHOD FOR MAKING 3α-HYDROXY, 3β- METHYL-5α-PREGNAN-20-ONE (GANAXOLONE)
Document Type and Number:
WIPO Patent Application WO/2011/019821
Kind Code:
A3
Abstract:
Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α- pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula.

Inventors:
SHAW, Kenneth (83 Steep Hill Road, Weston, Connecticut, 06883, US)
HUTCHISON, Alan (11 Fontainebleau Drive, Brick, New Jersey, 08723, US)
Application Number:
US2010/045176
Publication Date:
February 17, 2011
Filing Date:
August 11, 2010
Export Citation:
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Assignee:
MARINUS PHARMACEUTICALS, INC. (21 Business Park Drive, Branford, Connecticut, 06405, US)
SHAW, Kenneth (83 Steep Hill Road, Weston, Connecticut, 06883, US)
HUTCHISON, Alan (11 Fontainebleau Drive, Brick, New Jersey, 08723, US)
International Classes:
C07J5/00; A61K31/57; A61K31/575; A61P25/28; C07J9/00
Domestic Patent References:
WO2006010085A12006-01-26
WO2007062266A22007-05-31
Foreign References:
US3953429A1976-04-27
US6117994A2000-09-12
US20070141161A12007-06-21
Other References:
See also references of EP 2464653A2
Attorney, Agent or Firm:
MAXWELL, Leslie-Anne (Cantor Colburn LLP, 20 Church Street22nd Floo, Hartford Connecticut, 06103, US)
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