Title:
A METHOD OF MAKING A LAMINATED SUBSTRATE AND AN APA METHOD OF MAKING A LAMINATED SUBSTRATE AND AN APPARATUS FOR MARKING THE SUBSTRATE WITH REAGENT PARATUS FOR MARKING THE SUBSTRATE WITH REAGENT
Document Type and Number:
WIPO Patent Application WO1996034738
Kind Code:
A3
Abstract:
The invention relates to a method of making a laminated substrate for use in an immunodiagnostic device and a machine or apparatus for marking the substrate with reagent. The method of forming the laminated substrate creates a rollable chromatographic medium. The chromatographic medium can be biphasic or multiphasic. The biphasic chromatographic medium comprises a capture medium precast onto a plastic backing and a release medium. The release and capture media are bonded to a liner material such as a plastic film. The multiphasic chromatographic medium comprises a capture medium precast onto a plastic backing, a release medium, and a sample absorbent medium. The capture medium, the release medium and the sample absorbent medium are disposed on a liner material such as a plastic film. The biphasic and multiphasic laminates are prepared for use as immunoassays by a specially adapted machine or apparatus. The machine includes a leader, an unwind system, a reagent dispensing system, a substrate reject marking system, a drying system, and a rewind system. In one exemplary embodiment, the machine applies four reagents to the substrate. The particular reagents used in the machine will vary depending upon the immunoassay to be performed.
Inventors:
SISBARRO FREDERICK P
THOMSEN GLENN W
NAZARETH ALBERT R
THOMSEN GLENN W
NAZARETH ALBERT R
Application Number:
PCT/US1996/006088
Publication Date:
February 06, 1997
Filing Date:
May 01, 1996
Export Citation:
Assignee:
CARTER WALLACE (US)
International Classes:
B32B3/14; B65H39/16; G01N33/543; G01N31/22; G01N33/558; G01S17/88; (IPC1-7): B32B3/14; G01N33/52; B32B31/08
Domestic Patent References:
| WO1994001775A1 | 1994-01-20 | |||
| WO1994015215A1 | 1994-07-07 |
Foreign References:
| EP0374684A1 | 1990-06-27 | |||
| EP0353570A2 | 1990-02-07 | |||
| EP0291843A2 | 1988-11-23 | |||
| DE4314493A1 | 1994-11-10 | |||
| EP0297389A2 | 1989-01-04 | |||
| EP0420021A2 | 1991-04-03 |
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