Title:
METHOD OF MAKING A VACCINE
Document Type and Number:
WIPO Patent Application WO/2010/042919
Kind Code:
A3
Abstract:
The present invention provides a vaccine and method for making same which is effective to elicit a desired antibody against a target antigen comprising a primary immunogen and a secondary immunogen, wherein the primary immunogen is effective to elicit B cell receptors (BCRs) that are on the maturational pathway of the desired antibody and have an intermediate degree of somatic mutational diversity, and the secondary immunogen comprises an epitope of the desired target antibody and is effective to further diversify the BCRs sufficient to form mature BCRs having the identical or substantially identical sequence as the desired antibody.
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Inventors:
DIMITROV DIMITER S (US)
Application Number:
PCT/US2009/060303
Publication Date:
July 29, 2010
Filing Date:
October 11, 2009
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
DIMITROV DIMITER S (US)
DIMITROV DIMITER S (US)
International Classes:
A61K39/12; A61P31/18; A61P35/00
Foreign References:
| US7153509B2 | 2006-12-26 | |||
| US20070292390A1 | 2007-12-20 |
Other References:
BUCKNER C ET AL.: "Priming B cell-mediated anti-HIV envelope responses by vaccination allows for the long-term control of infection in macaques exposed to a R5-tropic SHIV.", VIROLOGY., vol. 320, no. 1, 1 March 2004 (2004-03-01), pages 167 - 180, XP004494617
ZHANG MY ET AL.: "Novel approaches for identification of broadly cross- reactive HIV-1 neutralizing human monoclonal antibodies and improvement of their potency.", CURR PHARM DES., vol. 13, no. 2, 2007, pages 203 - 212, XP009085271
PINILLA-IBARZ J ET AL.: "Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses.", BLOOD., vol. 95, no. 5, 1 March 2000 (2000-03-01), pages 1781 - 1787, XP008146658
XIAO X ET AL.: "Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens.", BIOCHEM BIOPHYS RES COMMUN., vol. 390, no. 3, 18 December 2009 (2009-12-18), pages 404 - 409, XP026770556
ZHANG MY ET AL.: "Novel approaches for identification of broadly cross- reactive HIV-1 neutralizing human monoclonal antibodies and improvement of their potency.", CURR PHARM DES., vol. 13, no. 2, 2007, pages 203 - 212, XP009085271
PINILLA-IBARZ J ET AL.: "Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses.", BLOOD., vol. 95, no. 5, 1 March 2000 (2000-03-01), pages 1781 - 1787, XP008146658
XIAO X ET AL.: "Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens.", BIOCHEM BIOPHYS RES COMMUN., vol. 390, no. 3, 18 December 2009 (2009-12-18), pages 404 - 409, XP026770556
Attorney, Agent or Firm:
CORLESS, Peter, F. et al. (P.O.box 55874Boston, MA, US)
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