Title:
METHOD FOR MANUFACTURING BONE-REGENERATION MATERIAL COMPRISING BIODEGRADABLE FIBERS BY USING ELECTROSPINNING METHOD
Document Type and Number:
WIPO Patent Application WO/2017/188435
Kind Code:
A1
Abstract:
There is a demand for a novel method for manufacturing, with commercial efficiency, a bone-regeneration material that contains calcium phosphate particles in a biodegradable fiber comprising PLGA by using electrospinning, and a novel bone-regeneration material manufactured using the method. According to the present invention, a PLGA resin is heated in a kneader so as to be softened until the viscosity of the resin becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is poured while the blade of the kneader is being rotated, and mixed with the softened PLGA resin. The mixture is kneaded by applying thermal and mechanical energy to the mixture through the continuous rotation of the blade of the kneader in the heated state, and aggregations of the calcium phosphate fine particles are disintegrated to prepare a composite in which the calcium phosphate fine particles are dispersed in the PLGA resin. The composite is dissolved by a solvent, and the PLGA resin is completely dissolved by the solvent through agitation for a prescribed period of time to prepare a spinning solution in which the calcium phosphate fine particles are dispersed without being aggregated in a solution having the PLGA resin dissolved therein. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.
Inventors:
KASUGA TOSHIHIRO (JP)
NISHIKAWA YASUTOSHI (JP)
NISHIKAWA YASUTOSHI (JP)
Application Number:
PCT/JP2017/016931
Publication Date:
November 02, 2017
Filing Date:
April 28, 2017
Export Citation:
Assignee:
NAT UNIV CORP NAGOYA INST OF TECH (JP)
ORTHOREBIRTH CO LTD (JP)
ORTHOREBIRTH CO LTD (JP)
International Classes:
A61L27/18; A61L27/12; A61L27/46; A61L27/58; D01D5/08; D01F1/02; D01F6/62
Domestic Patent References:
| WO2015005205A1 | 2015-01-15 | |||
| WO2016159240A1 | 2016-10-06 |
Other References:
ITO SHINGO ET AL.: "Mechanical-tensile strengths and cell -proliferative activities of electrospun poly(lactic-co-glycolic acid) composites containing beta-tricalcium phosphate", PHOSPHORUS RESEARCH BULLETIN, vol. 26, 2012, pages 109 - 112, XP055481969, ISSN: 0918-4783
FUJIKURA KIE ET AL.: "Preparation of electrospun fiber mats using siloxane-containing vaterite and biodegradable polymer hybrids for bone regeneration", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS, vol. 101 B, no. 8, December 2013 (2013-12-01), pages 1350 - 1358, XP055435503, ISSN: 1552-4973
See also references of EP 3381482A4
FUJIKURA KIE ET AL.: "Preparation of electrospun fiber mats using siloxane-containing vaterite and biodegradable polymer hybrids for bone regeneration", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS, vol. 101 B, no. 8, December 2013 (2013-12-01), pages 1350 - 1358, XP055435503, ISSN: 1552-4973
See also references of EP 3381482A4
Attorney, Agent or Firm:
NINOMIYA Katsuyuki (JP)
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