METHOD FOR MANUFACTURING CIS-5-HYDROXY-L-PIPECOLIC ACID

Title:

METHOD FOR MANUFACTURING CIS-5-HYDROXY-L-PIPECOLIC ACID

Document Type and Number:

WIPO Patent Application WO/2016/076159

Kind Code:

A1

Abstract:

A method for manufacturing cis-5-hydroxy-L-pipecolic acid, characterized in that cis-5-hydroxy-L-pipecolic acid is produced by causing 2-oxoglutarate-dependent L-pipecolic acid hydroxylase to act on L-pipecolic acid, the 2-oxoglutarate-dependent L-pipecolic acid hydroxylase including a polypeptide indicated by (A), (B), or (C). (A) A polypeptide having an amino acid sequence represented by SEQ ID NO: 4 or 11; (B) a polypeptide having an amino acid sequence in which one or several amino acids have been deleted, substituted, and/or added in an amino acid sequence represented by SEQ ID NO: 4 or 11, and further having 2-oxoglutarate-dependent L-pipecolic acid hydroxylase activity; or (C) a polypeptide having an amino acid sequence having 60% or greater identity with an amino acid sequence represented by SEQ ID NO: 4 or 11, and further having 2-oxoglutarate-dependent L-pipecolic acid hydroxylase activity.

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Inventors:

MIYAKE RYOMA (JP)
DEKISHIMA YASUMASA (JP)

Application Number:

PCT/JP2015/080960

Publication Date:

May 19, 2016

Filing Date:

November 02, 2015

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Assignee:

API CORP (JP)

International Classes:

C12P17/12; C12N9/02; C12N15/09

Domestic Patent References:

WO2013187438A1

2013-12-19

Other References:

DATABASE GenBank [o] 7 March 2015 (2015-03-07), "Definition: putative L-proline cis-4- hydroxylase [Xenorhabdus doucetiae", XP055381322, Database accession no. CDG16639
HARA, R. ET AL.: "Identification and characterization of 2-oxoglutarate-dependent dioxygenases catalyzing selective cis- hydroxylation of proline and pipecolinic acid from actinomycetes", JOURNAL OF BIOTECHNOLOGY, vol. 172, 2014, pages 55 - 58, XP028605277, ISSN: 0168-1656
See also references of EP 3219805A4

Attorney, Agent or Firm:

KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)

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