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Patent Searching and Data


Title:
METHOD FOR MANUFACTURING CYCLOPROPANE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/050339
Kind Code:
A1
Abstract:
Provided is an industrially useful method for manufacturing (1R,2S)-2-{[((2,4-dimethylpyrimidine-5-yl)oxy}methyl]-2-(3-fluorophenyl)-N-(5-fluoropyridine-2-yl)cyclopropane-1-carboxamide. In the present invention, (1R,2S)-2-{[((2,4-dimethylpyrimidine-5-yl)oxy}methyl]-2-(3-fluorophenyl)-N-(5-fluoropyridine-2-yl)cyclopropane-1-carboxamide (compound [A]) is manufactured by an industrially useful method by way of a novel compound. (Symbols in the formula are as described in the specification.)

Inventors:
YAMAUCHI KAZUHIRO (JP)
TOMOKAWA JUNICHI (JP)
Application Number:
JP2019/034882
Publication Date:
March 12, 2020
Filing Date:
September 05, 2019
Export Citation:
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Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
C07C67/347; B01J31/02; B01J31/14; B01J31/22; C07C59/56; C07C61/40; C07C69/753; C07C69/757; C07C309/73; C07D213/75; C07D307/93; C07D401/12; A61K31/506; C07B53/00; C07B61/00
Foreign References:
US20120165339A12012-06-28
JP2015509939A2015-04-02
Other References:
YU YOSHIDA ET AL.: "Discovery of (1R, 2S)-2-{[(2,4-Dimethyl pyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropir idin-2-yl)cyclopropanecarboxamide(E2006) : A potent and Efficacious Oral Orexin Receptor Antagonist.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, 2015, pages 4648 - 4664, XP055389586
NORIHITO OI ET AL.: "Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of the Orexin-2 Receptor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, 2013, pages 6371 - 6385, XP055690750
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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