Title:
METHOD FOR MANUFACTURING FIBRILS
Document Type and Number:
WIPO Patent Application WO/2019/054506
Kind Code:
A1
Abstract:
This method for manufacturing fibrils comprises: step (A) in which a fibroin containing a domain sequence represented by formula [(A)nmotif-REP]m is solubilized with a solubilizer to obtain a solubilization solution; step (B) in which the solubilization solution is diluted until the concentration of the solubilizer reaches the concentration at which aggregates of the fibroin are formed, and said concentration is maintained to thereby produce a suspension containing fibrils; and step (C) for recovering the fibrils produced in step (B).
Inventors:
KAMIKUBO HIRONARI (JP)
HAYASHI YUGO (JP)
SATO TAKEHIRO (JP)
HAYASHI YUGO (JP)
SATO TAKEHIRO (JP)
Application Number:
PCT/JP2018/034275
Publication Date:
March 21, 2019
Filing Date:
September 14, 2018
Export Citation:
Assignee:
SPIBER INC (JP)
International Classes:
C07K14/435; A61K8/64
Domestic Patent References:
| WO2002102845A1 | 2002-12-27 | |||
| WO2009119596A1 | 2009-10-01 | |||
| WO2017030197A1 | 2017-02-23 |
Foreign References:
| JP2011196001A | 2011-10-06 | |||
| JP2008169171A | 2008-07-24 | |||
| JPH0790182A | 1995-04-04 |
Other References:
TSENG, P. ET AL.: "Directed assembly of bio-inspired hierarchical materials with controlled nanofibrillar architectures", NATURE NANOTECHNOLOGY, vol. 12, no. 5, May 2017 (2017-05-01), pages 474 - 480, XP055582811, ISSN: 1748-3387, DOI: 10.1038/nnano.2017.4
SAI SUKEMOTO ET AL.: "Purification of antifungal active substances from wild Japanese silk moth fibroin powder", no. 28, 2003, pages 25
SAI SUKEMOTO ET AL.: "Purification of antifungal active substances from wild Japanese silk moth fibroin powder", no. 28, 2003, pages 25
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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