Title:
METHOD FOR MANUFACTURING HYDROPHILIC POLYMER-MODIFIED LIPOSOMES
Document Type and Number:
WIPO Patent Application WO/2011/125607
Kind Code:
A1
Abstract:
Disclosed are a method and device for manufacturing hydrophilic polymer-modified liposomes, said method having: a particle-size regulation step which produces a particle-size-regulated liposome liquid dispersion which contains liposomes having a mean diameter that has been controlled to within a prescribed range; a merging step which merges the aforementioned particle-size-regulated liposome liquid dispersion with hydrophilic polymers; a mixing step which mixes the aforementioned particle-size-regulated liposome liquid dispersion and the aforementioned hydrophilic polymers, yielding a hydrophilic polymer-modified liposome liquid dispersion containing hydrophilic polymer-modified liposomes; and a transfer step that sends the aforementioned hydrophilic polymer-modified liposome liquid dispersion to a liquid storage unit. In the merging step, the temperature of the particle-size-regulated liposome liquid dispersion is greater than or equal to the phase transition temperature of the main membrane material constituting the liposomes, which have a mean diameter that has been controlled to within a prescribed range. Furthermore, in the mixing step, the temperature of the liquid mixture comprising the aforementioned particle-size-regulated liposome liquid dispersion and the aforementioned hydrophilic polymers is greater than or equal to the aforementioned phase transition temperature. This method allows the manufacture of hydrophilic polymer-modified liposomes on an industrial level.
Inventors:
WACHI Megumi (1500 Inokuchi, Nakai-machi, Ashigarakami-gu, Kanagawa 51, 〒2590151, JP)
和地 恵 (〒51 神奈川県足柄上郡中井町井ノ口１５００番地 テルモ株式会社内 Kanagawa, 〒2590151, JP)
NAKAMURA Koji (1500 Inokuchi, Nakai-machi, Ashigarakami-gu, Kanagawa 51, 〒2590151, JP)
和地 恵 (〒51 神奈川県足柄上郡中井町井ノ口１５００番地 テルモ株式会社内 Kanagawa, 〒2590151, JP)
NAKAMURA Koji (1500 Inokuchi, Nakai-machi, Ashigarakami-gu, Kanagawa 51, 〒2590151, JP)
Application Number:
JP2011/057640
Publication Date:
October 13, 2011
Filing Date:
March 28, 2011
Export Citation:
Assignee:
TERUMO KABUSHIKI KAISHA (44-1, Hatagaya 2-chome Shibuya-k, Tokyo 72, 〒1510072, JP)
テルモ株式会社 (〒72 東京都渋谷区幡ヶ谷２丁目４４番１号 Tokyo, 〒1510072, JP)
WACHI Megumi (1500 Inokuchi, Nakai-machi, Ashigarakami-gu, Kanagawa 51, 〒2590151, JP)
和地 恵 (〒51 神奈川県足柄上郡中井町井ノ口１５００番地 テルモ株式会社内 Kanagawa, 〒2590151, JP)
テルモ株式会社 (〒72 東京都渋谷区幡ヶ谷２丁目４４番１号 Tokyo, 〒1510072, JP)
WACHI Megumi (1500 Inokuchi, Nakai-machi, Ashigarakami-gu, Kanagawa 51, 〒2590151, JP)
和地 恵 (〒51 神奈川県足柄上郡中井町井ノ口１５００番地 テルモ株式会社内 Kanagawa, 〒2590151, JP)
International Classes:
A61K9/127; A61K47/34; B01J13/20
Attorney, Agent or Firm:
WATANABE Mochitoshi et al. (Hayakawa-tonakai Bldg. 3F, 12-5 Iwamoto-cho 2-chome, Chiyoda-k, Tokyo 32, 〒1010032, JP)
Download PDF:
Claims: