Title:
METHOD FOR MANUFACTURING MOLDED ARTICLE
Document Type and Number:
WIPO Patent Application WO/2014/058003
Kind Code:
A1
Abstract:
By the present invention, by irradiating a molded article containing ultra-high-molecular-weight polyethylene and vitamin E with radiation at a temperature of 0°C or lower to cross-link the ultra-high-molecular-weight polyethylene, vitamin E radicals included in the molded article immediately after irradiation can be reduced, the generation of tocopherol quinone by subsequent transposition of vitamin E radicals can therefore be suppressed, and the biological safety of the molded article can be enhanced. By also storing the molded article for at least one day at a temperature of 0°C or lower after irradiation, the rate of reduction of vitamin E radicals or alkyl radicals generated by the irradiation can be decreased. The molded article thus obtained has excellent oxidation resistance and biological safety, and is therefore suitable for use as a medical implant.
Inventors:
TAJIMA KUNIHIKO (JP)
TOMITA NAOHIDE (JP)
UETSUKI KEITA (JP)
KAWASAKI TORU (JP)
IWADE HISASHI (JP)
TOMITA NAOHIDE (JP)
UETSUKI KEITA (JP)
KAWASAKI TORU (JP)
IWADE HISASHI (JP)
Application Number:
PCT/JP2013/077554
Publication Date:
April 17, 2014
Filing Date:
October 10, 2013
Export Citation:
Assignee:
NAT UNIV CORP KYOTO INST TECH (JP)
International Classes:
C08J7/00; A61L27/00; C08K5/1545; C08L23/06
Domestic Patent References:
| WO2010129514A2 | 2010-11-11 |
Foreign References:
| JP2010529213A | 2010-08-26 | |||
| JP2010538150A | 2010-12-09 | |||
| JP2006515777A | 2006-06-08 | |||
| JP2007536998A | 2007-12-20 | |||
| JP2006176924A | 2006-07-06 | |||
| JP2009144067A | 2009-07-02 |
Other References:
TORU KAWASAKI ET AL.: "Annealing ni yoru Denshisen Shosha dl-alpha-Tocophenol Kongo Cho Kobunshi-ryo Polyethylene-nai ni Okeru Vitamin E Radical no Shometsu to Kakyo Sokushin", THE JAPAN SOCIETY OF MECHANICAL ENGINEERS DAI 22 KAI BIO FRONTIER KOENKAI KOEN RONBUNSHU, 6 October 2011 (2011-10-06), pages 5 - 6
TORU KAWASAKI ET AL.: "Annealing Treatment Stabilizes Vitamin E Radicals and Accelerates the Cross-linking Reaction in Electron-Beam-Irradiated dl-alpha-Tocophenol-Blended Ultra High Molecular Weight Polyethylene", BIOTRIBOLOGY SYMPOSIUM, 5 November 2011 (2011-11-05), pages 52 - 53
TORU KAWASAKI ET AL.: "Annealing Treatment Stabilizes Vitamin E Radicals and Accelerates the Cross-linking Reaction in Electron-Beam-Irradiated dl-alpha-Tocophenol-Blended Ultra High Molecular Weight Polyethylene", BIOTRIBOLOGY SYMPOSIUM, 5 November 2011 (2011-11-05), pages 52 - 53
Attorney, Agent or Firm:
NAKATSUKASA, Shigeki et al. (JP)
Shigeki Nakamu (JP)
Shigeki Nakamu (JP)
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