METHOD FOR MANUFACTURING OPTICALLY ACTIVE 3-TERT-BUTOXYCARBONYLAMINO-2-FLUORO-1-PROPANOL

Title:

METHOD FOR MANUFACTURING OPTICALLY ACTIVE 3-TERT-BUTOXYCARBONYLAMINO-2-FLUORO-1-PROPANOL

Document Type and Number:

WIPO Patent Application WO/2011/062139

Kind Code:

A1

Abstract:

Provided is a three-step method for manufacturing optically active 3-tert-butoxycarbonylamino-2-fluoro-1-propanol. The provided method can dramatically reduce the amount of a palladium catalyst used and can complete the reaction in one cycle, thereby reducing manufacturing costs and simplifying the procedure. Furthermore, the final target substance is crystallized and purified through recrystallization, yielding a high-purity result. Also provided is optically active 3-tert-butoxycarbonylamino-2-fluoropropionic acid ester, a novel substance which is a key intermediate in the provided manufacturing method.

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Inventors:

ISHII AKIHIRO
MASUDA TAKASHI
YAMAZAKI TAKAKO
TSURUTA HIDEYUKI

Application Number:

PCT/JP2010/070287

Publication Date:

May 26, 2011

Filing Date:

November 15, 2010

Export Citation:

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Assignee:

CENTRAL GLASS CO LTD (JP)
ISHII AKIHIRO
MASUDA TAKASHI
YAMAZAKI TAKAKO
TSURUTA HIDEYUKI

International Classes:

C07C269/06; B01J23/44; C07B51/00; C07B53/00; C07C227/18; C07C227/30; C07C227/42; C07C229/20; C07C269/04; C07C269/08; C07C271/16; C07C271/22; C07B61/00

Domestic Patent References:

WO2008136745A1	2008-11-13
WO2008136746A1	2008-11-13
WO2007056280A1	2007-05-18

Attorney, Agent or Firm:

HASHIMOTO, Takeshi et al. (JP)
Hashimoto 剛 (JP)

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