Title:
METHOD FOR MANUFACTURING OPTICALLY ACTIVE 5-HYDROXY-3-KETOESTERS
Document Type and Number:
WIPO Patent Application WO/2015/030001
Kind Code:
A1
Abstract:
[Problem] The purpose of the present invention is to provide a method for manufacturing optically active 5-hydroxy-3-ketoesters with high yield and high stereoselectivity that can be used as a pharmaceutical intermediate. The purpose of the present invention is also to provide a manufacturing intermediate for a novel pharmaceutical product obtained using the method. [Solution] A novel manufacturing method for obtaining an optically active 5-hydroxy-3-ketoester compound with high yield and high stereoselectivity by allowing a substituted nitrogen-containing 5-6 member heteroaromatic ring compound to coexist in the presence of an optically active binaphthol-titanium complex in an asymmetrical aldol reaction using a 1,3-diene compound; and a novel manufacturing intermediate compound having a crystalline form.
Inventors:
TATEYAMA SHOUICHI (JP)
NAITOU SHINYA (JP)
TAKADA YASUTAKA (JP)
ISHIDA MARIKO (JP)
KITSUYAMA HIROHIDE (JP)
NAITOU SHINYA (JP)
TAKADA YASUTAKA (JP)
ISHIDA MARIKO (JP)
KITSUYAMA HIROHIDE (JP)
Application Number:
PCT/JP2014/072308
Publication Date:
March 05, 2015
Filing Date:
August 26, 2014
Export Citation:
Assignee:
NISSAN CHEMICAL IND LTD (JP)
International Classes:
C07C67/00; C07C69/738; C07D215/14; C07D239/42; C07B53/00; C07B61/00
Domestic Patent References:
| WO2003042180A1 | 2003-05-22 | |||
| WO2011121598A1 | 2011-10-06 | |||
| WO2009128091A2 | 2009-10-22 |
Foreign References:
| JP2009500388A | 2009-01-08 |
Attorney, Agent or Firm:
HANABUSA, Tsuneo et al. (JP)
Sepal Tsuneo (JP)
Sepal Tsuneo (JP)
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