Title:
METHOD FOR MANUFACTURING ORALLY DISINTEGRATING TABLET, AND ORALLY DISINTEGRATING TABLET
Document Type and Number:
WIPO Patent Application WO/2021/002411
Kind Code:
A1
Abstract:
Provided is a method for manufacturing an orally disintegrating tablet, in which adequate hardness for preventing breakage of the tablet during transport or handling by a medical practitioner or a patient is provided while rapid disintegration is maintained. A method for manufacturing an orally disintegrating tablet according to an embodiment of the present invention comprises spraying or dropping a liquid including hydroxypropyl cellulose having a viscosity in a 2% aqueous solution at 20°C of 150 mPa∙s to 400 mPa∙s into an additive, and performing fluid bed granulation. The liquid including hydroxypropyl cellulose may be sprayed or dropped into the additive so that the content of the hydroxypropyl cellulose with respect to 100 wt% of the orally disintegrating tablet is 0.2 wt% to 5 wt%.
Inventors:
IKUNO KOHEI (JP)
UCHIDA SAE (JP)
UCHIDA SAE (JP)
Application Number:
PCT/JP2020/025940
Publication Date:
January 07, 2021
Filing Date:
July 02, 2020
Export Citation:
Assignee:
SAWAI SEIYAKU KK (JP)
International Classes:
A61K45/00; A61K9/20; A61K47/38
Foreign References:
| JP2014224079A | 2014-12-04 | |||
| JP2007269783A | 2007-10-18 | |||
| JP2001151671A | 2001-06-05 |
Attorney, Agent or Firm:
TAKAHASHI, HAYASHI AND PARTNER PATENT ATTORNEYS, INC. (JP)
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