Title:
METHOD FOR MANUFACTURING USEFUL SUBSTANCE IN WHICH HIGH-DENSITY CULTURED STRAIN OF FILAMENTOUS FUNGI IS USED
Document Type and Number:
WIPO Patent Application WO/2014/073674
Kind Code:
A1
Abstract:
A problem to be resolved by the present invention is to allow filamentous fungi to be cultured in high density, and a useful substance to be thereby mass-produced. The present invention provides a method for manufacturing a substance, the method including: a step for culturing mutant-type filamentous fungi that do not express α-1,3-glucan, and causing the filamentous fungi to produce the substance; and a step for collecting the substance that was obtained.
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Inventors:
ABE KEIETSU (JP)
GOMI KATSUYA (JP)
YOSHIMI KEI (JP)
GOMI KATSUYA (JP)
YOSHIMI KEI (JP)
Application Number:
PCT/JP2013/080352
Publication Date:
May 15, 2014
Filing Date:
November 08, 2013
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
C12N1/14; C12P1/02; C12N15/09
Foreign References:
| JP2010227032A | 2010-10-14 | |||
| JP2010172343A | 2010-08-12 | |||
| JP2001046078A | 2001-02-20 | |||
| JP2005052116A | 2005-03-03 | |||
| JP2009118783A | 2009-06-04 | |||
| JPH11506025A | 1999-06-02 | |||
| JP2007508022A | 2007-04-05 | |||
| JP2002218970A | 2002-08-06 | |||
| JP2010227031A | 2010-10-14 | |||
| JP2010107126A | 2010-05-13 | |||
| JP2010220590A | 2010-10-07 |
Other References:
I. POLACHECK ET AL.: "Aspergillus nidulans Mutant Lacking a-(1,3)- Glucan, Melanin, and Cleistothecia", JOURNAL OF BACTERIOLOGY, vol. 132, no. 2, 1977, pages 650 - 656, XP055255462
C. HENRY ET AL.: "al,3 Glucans Are Dispensable in Aspergillus fumigatus", EUKARYOTIC CELL, vol. 11, no. 1, 2012, pages 26 - 29, XP055255465
HIROKI SATO ET AL.: "Kojikin no Ekitai Baiyo ni Okeru a-1,3-glucan Gosei Koso Idenshi no Hatsugen to Kinshi Keitai eno Kan'yo", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2011, 2011, pages 95, XP008179267
MASAHIRO HITOSUGI ET AL.: "Aspergillus nigulans ni Okeru a-1,3-glucan Kessonkabu no Komitsudo Baiyosei to Busshitsu Seisansei no Hyoka", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2013, 5 March 2013 (2013-03-05), pages 1626, XP008179276
HOGAN, L. H. ET AL.: "Altered expression of surface a-1,3-glucan in genetically related strains of Blastomyces dermatitidis that differ in virulence", INFECT. IMMUN., vol. 62, 1994, pages 3543 - 3546
RAPPLEYE, C.A. ET AL.: "RNA interference in Histoplasma capsulatumdemonstrates a rolefor a-(1,3)-glucan in virulence", MOL. MICROBIOL., vol. 53, 2004, pages 153 - 165
BEAUVAIS, A. ET AL.: "Two a(1-3) Glucan Synthases with Different Functions in Aspergillus fumigates", APPL. ENVIRON. MICROBIOL., vol. 71, 2005, pages 1531 - 1538, XP055280600, DOI: doi:10.1128/AEM.71.3.1531-1538.2005
MAUBON, D. ET AL.: "AGS3, an a(1-3)glucan synthase gene family member of Aspergillusfumigatus, modulates mycelium growth in the lung of experimentally infected mice", FUNGAL GENET. BIOL., vol. 43, 2006, pages 366 - 375
HENRY C. ET AL.: "a1,3 glucansare dispensable in Aspergillus fumigatus", EUKARIOT. CELL, vol. 11, 2011, pages 26 - 29
FURUKAWA ET AL., BIOSCI. BIOTHECHNOL. BIOCHEM., vol. 71, no. 7, 2007, pages 1724 - 1730
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 78, no. 12, June 2012 (2012-06-01), pages 4126 - 4133
C. HENRY ET AL.: "al,3 Glucans Are Dispensable in Aspergillus fumigatus", EUKARYOTIC CELL, vol. 11, no. 1, 2012, pages 26 - 29, XP055255465
HIROKI SATO ET AL.: "Kojikin no Ekitai Baiyo ni Okeru a-1,3-glucan Gosei Koso Idenshi no Hatsugen to Kinshi Keitai eno Kan'yo", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2011, 2011, pages 95, XP008179267
MASAHIRO HITOSUGI ET AL.: "Aspergillus nigulans ni Okeru a-1,3-glucan Kessonkabu no Komitsudo Baiyosei to Busshitsu Seisansei no Hyoka", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2013, 5 March 2013 (2013-03-05), pages 1626, XP008179276
HOGAN, L. H. ET AL.: "Altered expression of surface a-1,3-glucan in genetically related strains of Blastomyces dermatitidis that differ in virulence", INFECT. IMMUN., vol. 62, 1994, pages 3543 - 3546
RAPPLEYE, C.A. ET AL.: "RNA interference in Histoplasma capsulatumdemonstrates a rolefor a-(1,3)-glucan in virulence", MOL. MICROBIOL., vol. 53, 2004, pages 153 - 165
BEAUVAIS, A. ET AL.: "Two a(1-3) Glucan Synthases with Different Functions in Aspergillus fumigates", APPL. ENVIRON. MICROBIOL., vol. 71, 2005, pages 1531 - 1538, XP055280600, DOI: doi:10.1128/AEM.71.3.1531-1538.2005
MAUBON, D. ET AL.: "AGS3, an a(1-3)glucan synthase gene family member of Aspergillusfumigatus, modulates mycelium growth in the lung of experimentally infected mice", FUNGAL GENET. BIOL., vol. 43, 2006, pages 366 - 375
HENRY C. ET AL.: "a1,3 glucansare dispensable in Aspergillus fumigatus", EUKARIOT. CELL, vol. 11, 2011, pages 26 - 29
FURUKAWA ET AL., BIOSCI. BIOTHECHNOL. BIOCHEM., vol. 71, no. 7, 2007, pages 1724 - 1730
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 78, no. 12, June 2012 (2012-06-01), pages 4126 - 4133
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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