Title:
METHOD FOR MASS PROLIFERATION OF NATURAL KILLER CELLS USING MACROPHAGES AND INFLAMMATORY SUBSTANCES
Document Type and Number:
WIPO Patent Application WO/2018/110892
Kind Code:
A3
Abstract:
A method for mass proliferation of natural killer cells according to the present invention comprises: a first step of collecting and isolating lymphocytes from human blood; a second step of adding poly gamma glutamic acid to a cell suspension in which the isolated lymphocytes are suspended in a culture solution and then culturing the same; and a third step of harvesting the cells from the culture solution by centrifugation, wherein the poly gamma glutamic acid has a molecular weight of 1,000 kDa to 5,000 kDa.
Inventors:
MOON GUY YOUNG (KR)
LEE EUI SOO (KR)
LIM GO EUN (KR)
CHOI EUN YOUNG (KR)
LEE EUI SOO (KR)
LIM GO EUN (KR)
CHOI EUN YOUNG (KR)
Application Number:
PCT/KR2017/014215
Publication Date:
January 24, 2019
Filing Date:
December 06, 2017
Export Citation:
Assignee:
IMMUNISBIO CO LTD (KR)
International Classes:
C12N5/0783
Foreign References:
| KR20090127973A | 2009-12-15 | |||
| KR101039843B1 | 2011-06-09 | |||
| KR20160066837A | 2016-06-13 | |||
| KR20120090485A | 2012-08-17 |
Other References:
JEONG, KI HEON ET AL.: "Poly-y-Glutamic Acid Modifies Cytokine Release In Vitro", J. KYUNGHEE UNIV. MED. CENT., vol. 27, no. 1, 2011, pages 34 - 42
Attorney, Agent or Firm:
JUNG, Seung-hun (KR)
Download PDF: