Title:
METHOD OF MS/MS MASS SPECTROMETRY
Document Type and Number:
WIPO Patent Application WO/2013/171493
Kind Code:
A3
Abstract:
A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are mass analysed and a second mode in which the parent ions are subjected to Electron Capture Dissociation ("ECD") at atmospheric pressure so as to produce fragment ions which are then mass analysed. The parent ions are associated with their fragment ions based on the times at which they were detected. This method enables parent ions to be associated with their fragment ions, even when the ECD fragmentation is performed at atmospheric pressure.
Inventors:
BROWN JEFFERY MARK (GB)
GREEN MARTIN RAYMOND (GB)
PRINGLE STEVEN DEREK (GB)
GREEN MARTIN RAYMOND (GB)
PRINGLE STEVEN DEREK (GB)
Application Number:
PCT/GB2013/051259
Publication Date:
November 13, 2014
Filing Date:
May 16, 2013
Export Citation:
Assignee:
MICROMASS LTD (GB)
International Classes:
H01J49/00
Domestic Patent References:
| WO2011058381A1 | 2011-05-19 | |||
| WO2012066329A1 | 2012-05-24 |
Foreign References:
| US20110226941A1 | 2011-09-22 | |||
| US20080173807A1 | 2008-07-24 |
Other References:
DAMON B. ROBB ET AL: "Liquid Chromatography-Atmospheric Pressure Electron Capture Dissociation Mass Spectrometry for the Structural Analysis of Peptides and Proteins", ANALYTICAL CHEMISTRY, vol. 84, no. 9, 11 April 2012 (2012-04-11), pages 4221 - 4226, XP055117689, ISSN: 0003-2700, DOI: 10.1021/ac300648g
Attorney, Agent or Firm:
CHIVA, Andrew Peter (10 Salisbury Square, London EC4Y 8JD, GB)
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