Title:
METHOD FOR MEASURING COMPLEMENT-DEPENDENT BACTERICIDAL FUNCTION WITH RESPECT TO PNEUMOCOCCI
Document Type and Number:
WIPO Patent Application WO/2016/204265
Kind Code:
A1
Abstract:
The present invention pertains to a method for measuring complement-dependent bactericidal function with respect to pneumococci, and provides a method for measuring activity which can perform measurements with respect to all capsular serotypes of pneumococcus. This method employs the measurement of complement-dependent bactericidal function with respect to pneumococci, using capsule deleted pneumococci, that is to say noncapsular or close to noncapsular, or transparent pneumococci. With this method it is possible to measure complement-dependent bactericidal function with respect to all capsular serotypes of pneumococcus.
Inventors:
AKEDA YUKIHIRO (JP)
MIYATAKE HIROSHI (JP)
PIAO ZHENYU (JP)
KOIZUMI YUKA (JP)
MIYATAKE HIROSHI (JP)
PIAO ZHENYU (JP)
KOIZUMI YUKA (JP)
Application Number:
PCT/JP2016/068069
Publication Date:
December 22, 2016
Filing Date:
June 17, 2016
Export Citation:
Assignee:
THE RES FOUND FOR MICROBIAL DISEASES OF OSAKA UNIV (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
C12Q1/02; G01N33/15; C07K16/12; C12N1/20; C12N5/078; C12N5/0787
Domestic Patent References:
| WO2014045621A1 | 2014-03-27 |
Foreign References:
| JP2012184236A | 2012-09-27 |
Other References:
DANIELS C.C. ET AL.: "Modified Opsonization, Phagocytosis, and Killing Assays To Measure Potentially Protective Antibodies against Pneumococcal Surface Protein A", CLIN. VACCINE IMMUNOL., vol. 20, no. 10, 2013, pages 1549 - 1558, XP055337647
ONWUBIKO C. ET AL.: "Characterization of Streptococcus pneumoniae Isolated from Children with Otitis Media", FEMS IMMUNOL. MED. MICROBIOL., vol. 50, 2007, pages 119 - 125, XP055337649
See also references of EP 3312287A4
ONWUBIKO C. ET AL.: "Characterization of Streptococcus pneumoniae Isolated from Children with Otitis Media", FEMS IMMUNOL. MED. MICROBIOL., vol. 50, 2007, pages 119 - 125, XP055337649
See also references of EP 3312287A4
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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