Title:
METHOD FOR MEASURING OR IDENTIFYING A COMPONENT OF INTEREST IN SPECIMENS
Document Type and Number:
WIPO Patent Application WO/2021/201295
Kind Code:
A1
Abstract:
A method for identifying a target component of interest in a specimen by probe electrospray ionization mass spectrometry, including: (1) adsorbing the target component of interest onto an extraction phase for adsorbing the target component of interest from the specimen by immersing a probe into the specimen, wherein the probe is at least partially coated with the extraction phase; (2) removing the probe from the specimen and optionally quick rising it by dipping in or spraying water or acetone/water mixtures; (3) adhering solvent to the extraction phase; (4) desorbing the target component of interest into the solvent from the extraction phase; (5) electrospraying the target component of interest desorbed in the solvent adhered to the probe on the ionization source at atmospheric pressure by applying a voltage to the probe to spray aerosolized ionized droplets out of the probe; and (6) identifying the target component of interest present in the aerosolized ionized droplets.
Inventors:
PAWLISZYN B JANUSZ (CA)
THIRUKUMARAN MILAAN (CA)
SINGH VAROON (CA)
ARAO YOHEI (US)
FUJITO YUKA (US)
NISHIMURA MASAYUKI (US)
OGURA TAIRO (JP)
THIRUKUMARAN MILAAN (CA)
SINGH VAROON (CA)
ARAO YOHEI (US)
FUJITO YUKA (US)
NISHIMURA MASAYUKI (US)
OGURA TAIRO (JP)
Application Number:
PCT/JP2021/014418
Publication Date:
October 07, 2021
Filing Date:
April 03, 2021
Export Citation:
Assignee:
JP SCIENT LIMITED (CA)
SHIMADZU CORP (JP)
SHIMADZU CORP (JP)
International Classes:
H01J49/16; G01N1/40; H01J49/04
Domestic Patent References:
| WO2015188282A1 | 2015-12-17 | |||
| WO2010047399A1 | 2010-04-29 |
Foreign References:
| US20150318160A1 | 2015-11-05 | |||
| CN104134606A | 2014-11-05 | |||
| US202063004703P | 2020-04-03 | |||
| JP2014044110A | 2014-03-13 | |||
| JP4862167B2 | 2012-01-25 |
Other References:
DEVELOPMENT AND APPLICATION OF SOLID-PHASE MICROEXTRACTION PROBE ELECTROSPRAY IONIZATION, 21 December 2020 (2020-12-21)
SOLID-PHASE MICROEXTRACTION-PROBE ELECTROSPRAY IONIZATION DEVICES FOR SCREENING AND QUANTITATING DRUGS OF ABUSE IN SMALL AMOUNTS OF BIOFLUIDS, 18 March 2021 (2021-03-18)
SOLID-PHASE MICROEXTRACTION-PROBE ELECTROSPRAY IONIZATION DEVICES FOR SCREENING AND QUANTITATING DRUGS OF ABUSE IN SMALL AMOUNTS OF BIOFLUIDS, 18 March 2021 (2021-03-18)
Attorney, Agent or Firm:
KOMAI Shinji (JP)
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