Title:
METHOD FOR MEASURING NGLY1 ACTIVITY IN CELL LYSATE AND PROBE TO BE USED THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/058527
Kind Code:
A1
Abstract:
A compound represented by formula (1) [in formula (1): Xaa, Xaa1, Xaa2 and Xaa3 independently represent an arbitrary amino acid residue; n represents an integer of 1-20; R is nil or represents a straight-chain or branched sugar chain consisting of 1-20 monosaccharide residues; and X1 represents a fluorescent substance] that is useful as a probe for measuring NGLY1 activity. [Chemical formula 1]
Inventors:
SUZUKI TADASHI (JP)
HIRAYAMA HIROTO (JP)
MURASE TAKEFUMI (JP)
SAITO FUMIE (JP)
MATSUDA YUKA (JP)
HIRAYAMA HIROTO (JP)
MURASE TAKEFUMI (JP)
SAITO FUMIE (JP)
MATSUDA YUKA (JP)
Application Number:
PCT/JP2022/036221
Publication Date:
April 13, 2023
Filing Date:
September 28, 2022
Export Citation:
Assignee:
RIKEN (JP)
GLYTECH INC (JP)
GLYTECH INC (JP)
International Classes:
C07K2/00; C07K5/12; C07K7/64; C07K9/00
Foreign References:
| JP2019182757A | 2019-10-24 |
Other References:
UEMURA RYOTA, OGURA MIKAKO, MATSUMARU CHIHIRO, AKIYAMA TSUYOSHI, MAEDA MEGUMI, KIMURA YOSHINOBU: "Novel assay system for acidic Peptide: N -glycanase (aPNGase) activity in crude plant extract", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, JP, vol. 82, no. 7, 3 July 2018 (2018-07-03), JP , pages 1172 - 1175, XP093057380, ISSN: 0916-8451, DOI: 10.1080/09168451.2018.1459464
NOZOMI ISHII; CHIE SUNAGA; KANAE SANO; CHENGCHENG HUANG; KENTA IINO; YUJI MATSUZAKI; TADASHI SUZUKI; ICHIRO MATSUO: "A New Fluorogenic Probe for the Detection of endo‐β‐N‐Acetylglucosaminidase", CHEMBIOCHEM, JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 19, no. 7, 16 February 2018 (2018-02-16), Hoboken, USA, pages 660 - 663, XP072198524, ISSN: 1439-4227, DOI: 10.1002/cbic.201700662
KUROGOCHI MASAKI: "Glycan Remodeling of Glycoproteins Using ENGases", TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, FUJISHIRO, JP, vol. 30, no. 177, 25 November 2018 (2018-11-25), JP , pages E209 - E219, XP055968981, ISSN: 0915-7352, DOI: 10.4052/tigg.1764.1E
NOZOMI ISHII; CHIE SUNAGA; KANAE SANO; CHENGCHENG HUANG; KENTA IINO; YUJI MATSUZAKI; TADASHI SUZUKI; ICHIRO MATSUO: "A New Fluorogenic Probe for the Detection of endo‐β‐N‐Acetylglucosaminidase", CHEMBIOCHEM, JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 19, no. 7, 16 February 2018 (2018-02-16), Hoboken, USA, pages 660 - 663, XP072198524, ISSN: 1439-4227, DOI: 10.1002/cbic.201700662
KUROGOCHI MASAKI: "Glycan Remodeling of Glycoproteins Using ENGases", TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, FUJISHIRO, JP, vol. 30, no. 177, 25 November 2018 (2018-11-25), JP , pages E209 - E219, XP055968981, ISSN: 0915-7352, DOI: 10.4052/tigg.1764.1E
Attorney, Agent or Firm:
MATSUNUMA Yasushi et al. (JP)
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