METHOD FOR MEASURING OCCUPANCY RATE OF SPECIFIC BINDING SUBSTANCES IN CELL POPULATION

WIPO Patent Application WO/2019/031444

A1

Provided is a method for measuring the occupancy rate of a first specific binding substance in a cell population, the method including causing the cell population to come into contact with second and third specific binding substances, and measuring the number of cells to which the second and third specific binding substances are bonded, wherein the first, second, and third specific binding substances all bond to a target cell surface protein, the occupancy rate is the proportion of cells, from among cells expressing the target cell surface protein, to which the first specific binding substance binds, the second specific binding substance competes with the first specific binding substance, the third specific binding substance does not compete with the first specific binding substance, and the occupancy rate (%) is the value calculated by the formula: (1- (the number of cells to which the second specific binding substance is bonded/the number of the cells to which the third specific binding substance is bonded)) × 100.

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MATSUMOTO KOICHIRO (JP)
YANAGIHARA TOYOSHI (JP)
TANAKA KENTARO (JP)

PCT/JP2018/029390

February 14, 2019

August 06, 2018

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UNIV KYUSHU NAT UNIV CORP (JP)

G01N33/53; A61K39/395; A61P35/00

WO2004054616A1

2004-07-01

JP2016536314A	2016-11-24
JP2015534949A	2015-12-07
US20160251436A1	2016-09-01
JP2017152735A	2017-08-31

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See also references of EP 3667318A4
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TANAI Sumio et al. (JP)

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