Title:
METHOD FOR MEASURING REACTIVITY OF FVIII
Document Type and Number:
WIPO Patent Application WO/2016/047652
Kind Code:
A1
Abstract:
It was attempted to produce a substance that neutralizes the activity of a bispecific antibody having FVIII function-mimicking activity, and to devise a method for measuring FVIII reactivity whereby accuracy is maintained even in the presence of this bispecific antibody. As a result, it was discovered that FVIII activity in the plasma of a hemophilia A patient can be accurately evaluated by an APTT-based one-stage clotting assay, and further discovered that the FVIII inhibitor titer in the plasma of a hemophilia A patient having an inhibitor to FVIII can be accurately evaluated by an APTT-based Bethesda assay.
Inventors:
NOGAMI KEIJI (JP)
SHIMA MIDORI (JP)
SOEDA TETSUHIRO (JP)
KITAZAWA TAKEHISA (JP)
SHIMA MIDORI (JP)
SOEDA TETSUHIRO (JP)
KITAZAWA TAKEHISA (JP)
Application Number:
PCT/JP2015/076848
Publication Date:
March 31, 2016
Filing Date:
September 24, 2015
Export Citation:
Assignee:
PUBLIC UNIVERSITY CORP NARA MEDICAL UNIVERSITY (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K16/36; G01N33/86; G01N33/53
Domestic Patent References:
| WO2014050926A1 | 2014-04-03 |
Foreign References:
| JP2012082201A | 2012-04-26 | |||
| US20130330345A1 | 2013-12-12 |
Other References:
MUTO A. ET AL.: "Anti-factor IXa/X bispecific antibody (ACE910): hemostatic potency against ongoing bleeds in a hemophilia A model and the possibility of routine supplementation, Journal of Thrombosis and Haemostasis", SUPPORTING INFORMATION, vol. 12, no. 2, February 2014 (2014-02-01), pages 206 - 213, XP055214235
SAMPEI Z. ET AL.: "Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity", PLOS ONE, vol. 8, no. 2, 2013, pages e57479, XP055127871, DOI: doi:10.1371/journal.pone.0057479
SAMPEI Z. ET AL.: "Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity", PLOS ONE, vol. 8, no. 2, 2013, pages e57479, XP055127871, DOI: doi:10.1371/journal.pone.0057479
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
Masao Haruna (JP)
Masao Haruna (JP)
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