Title:
METHOD FOR MEASURING TARGET ANTIGEN, AND INSOLUBLE PARTICLES AND TARGET ANTIGEN MEASUREMENT KIT USED THEREIN
Document Type and Number:
WIPO Patent Application WO/2022/153898
Kind Code:
A1
Abstract:
Disclosed are insoluble particles comprising a particulate carrier and an antibody to a target antigen, said antibody being carried on the particulate carrier, wherein the C-terminal amino acid in a heavy chain of the antibody is lysine.
Inventors:
OGASAWARA DAISUKE (JP)
SHIMOMOTO MASAKO (JP)
YAMAMOTO KIMITAKA (JP)
ISHIKAWA HARUTO (JP)
SHIMOMOTO MASAKO (JP)
YAMAMOTO KIMITAKA (JP)
ISHIKAWA HARUTO (JP)
Application Number:
PCT/JP2022/000106
Publication Date:
July 21, 2022
Filing Date:
January 05, 2022
Export Citation:
Assignee:
DENKA COMPANY LTD (JP)
International Classes:
C07K16/00; C07K17/00; C12N15/13; G01N33/531; G01N33/543
Domestic Patent References:
| WO2007084693A2 | 2007-07-26 | |||
| WO2014116749A1 | 2014-07-31 |
Foreign References:
| CN102169119A | 2011-08-31 | |||
| JP2019103502A | 2019-06-27 |
Other References:
HU ZHILAN, ET AL.: "Evaluation of Heavy Chain C-Terminal Deletions on Productivity and Product Quality of Monoclonal Antibodies in Chinese Hamster Ovary (CHO) Cells", BIOTECHNOL. PROG., vol. 33, no. 3, 24 March 2017 (2017-03-24), pages 786 - 794, XP055950277, DOI: 10.1002/btpr.2444
ZHANG XINTAO; TANG HONGPING; SUN YA-TING; LIU XUPING; TAN WEN-SONG; FAN LI: "Elucidating the effects of arginine and lysine on a monoclonal antibody C-terminal lysine variation in CHO cell cultures", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 99, no. 16, 7 May 2015 (2015-05-07), Berlin/Heidelberg, pages 6643 - 6652, XP035521106, ISSN: 0175-7598, DOI: 10.1007/s00253-015-6617-y
ZHANG XINTAO; TANG HONGPING; SUN YA-TING; LIU XUPING; TAN WEN-SONG; FAN LI: "Elucidating the effects of arginine and lysine on a monoclonal antibody C-terminal lysine variation in CHO cell cultures", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 99, no. 16, 7 May 2015 (2015-05-07), Berlin/Heidelberg, pages 6643 - 6652, XP035521106, ISSN: 0175-7598, DOI: 10.1007/s00253-015-6617-y
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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